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- W2379654207 abstract "Objective To study the effect of sub-hypothermia on the expressions of Nogo-A and growth-associated protein-43(GAP-43),and to provide theoretic references for its clinical application.Methods Neonatal rabbits were divided into control group,sub-hypothermia group and room temperature group randomly.Protein Nogo-A and GAP-43 of each specimen were measured by immunohistochemical assays and the number of positive cell was calculated and compared among groups in order to study preliminarily the effects on gene expression of Nogo-A and GAP-43 after sub-hypothermia treatment.Results Comparing the average number of positive cells of Nogo-A and GAP-43,sub-hypothermia group and control group had significant difference with room temperature group(qNogo-A(Ⅲ,Ⅱ)=8.83,qgap-43(Ⅱ,Ⅲ)=11.65,P0.01;qNogo-A(Ⅲ,Ⅰ)= 11.16,qgap-43(Ⅰ,Ⅲ)=13.98,P0.01).Conclusions Sub-hypothermia can inhibit Nogo-A expression and maintain the expression of GAP-43 at a near normal level,which will be benefit the regeneration of neurons in neonatal rabbits suffering from hypoxic-ischemic brain damage." @default.
- W2379654207 created "2016-06-24" @default.
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- W2379654207 date "2007-01-01" @default.
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- W2379654207 title "The effect of sub-hypothermia on expressions of nogo-A and growth-associated protein-43 in neonatal rabbit" @default.
- W2379654207 hasPublicationYear "2007" @default.
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