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- W2379711887 abstract "In order to explore the radio-protective mechanism of treatment with nitroxides R-1 on the human liver cell L-02 was used as a model of target,and L-02 cells were divided into the control,drug,irradiation and combination groups.The samples of drug and irradiation groups were given 0.25μmol / L of R-1 and exposed to 4Gy of ~(60)Coγ-rays irradiation respectively;the combination group received both treatments;whereas there was no any treatment with the control group.The cell cycle was measured by flow cytometry;the enzyme activity of SOD and GSH was detected by chemiluminescence and spectrophotometric method,respectively meanwhile the concentration of MDA and ROS was measured by TBA and DCFH-DA,respectively.The expression of p53,Bcl-2,Bax and caspase-3 protein was observed by western blot.The results show that compared with irradiation group,the G_2 cell cycle arrest was relieved(determined at 48 h,G_2 phase proportion of the cell was(29.4±3.40):(44.01±2.71);t=6A6,P0.05,the enzyme activity of SOD was(97.03±5.99):(50.94±5.47);t=9.84,p0.05 and GSH was(16.56±0.91):(7.49±0.54); t=14.81,p0.05 meanwhile the concentration of MDA was(2.87±0.33):(4.93±0.17);1=9.56,p0.05 and ROS was (45.33±3.79):(75.67±4.7);t=8.67,p0.05.It was found that the expression of p53,Bax and caspase-3 decreased significantly, while the expression of Bcl-2 increased in the combination group.This experiment indicates that nitroxides R-1 can protect the L-02 cell from radiation damage effectively by removing the free radical in cells." @default.
- W2379711887 created "2016-06-24" @default.
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- W2379711887 date "2011-01-01" @default.
- W2379711887 modified "2023-09-25" @default.
- W2379711887 title "Radioprotective mechanism of nitroxides R-1 on human liver cell L-02" @default.
- W2379711887 hasPublicationYear "2011" @default.
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