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- W2379723340 abstract "Objective To screen the in vitro cytotoxicity of ten compounds from Rhodomela confervoides and investigate the antitumor activities of ethanol extract from R. confervoides (EERC) on S_ 180 mice. Methods Cytotoxicity of ten compounds was obtained by SRB and MTT assays. S_ 180 mice were used to evaluate the antitumor activities in vivo of EERC (Cytoxan as positive drug). LD_ 50 , tumor inhibition rate, indices of thymus and spleen, multiplication of spleen lymphocyte (MTT assay), IgA, IgG, IgM, and apoptosis rate of spleen lymphocyte were detected, respectively. The data were analyzed by software SPSS. Results Five compounds as 4, 4′-methylene-bis[5, 6-dibromo-1, 2-benzenediol] (Ⅰ), 3-bromo-4-[2, 3-dibromo-4, 5-dihydroxybenzyl] methyl-5-(methoxymethyl)-1, 2-benzenediol (Ⅱ), 3-bromo-4, 5-bis (2, 3-dibromo-4, 5-dihydroxybenzyl)-1, 2-benzenediol (Ⅲ), bis (2, 3-dibromo-4, 5-dihydroxybenzyl) ether (Ⅳ), and 3-bromo-4-[2, 3-dibromo-4, 5-dihydroxyphenyl] methyl-5-(ethoxymethyl)1, 2-benzenediol (Ⅴ) showed cytotoxicity to human lung cancer cell lines A-549. Tumor inhibitory rate of EERC in middle-dose group (1 g/kg) was significantly higher than that in the other groups, while the indices of thymus and spleen were increased obviously. Groups of EERC showed inhibition on multiplication of spleen lymphocyte. Concentration of IgA and IgG maintained a stable level in all groups. IgM was increased significantly in middle-dose group of EERC. Apoptosis rate of spleen lymphocyte was increased in middle- and high-dose groups. Conclusion Some compounds from R. confervoides showed certain cytotoxicity. The EERC has obvious antitumor effect on S_ 180 mice and can enhance the immune function of organism." @default.
- W2379723340 created "2016-06-24" @default.
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- W2379723340 date "2005-01-01" @default.
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- W2379723340 title "Antitumor activities of Rhodomela confervoides" @default.
- W2379723340 hasPublicationYear "2005" @default.
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