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- W2379728446 abstract "OBJECTIVE To investigate whether Aurora A is involved in prostate cancer carcinogenesis. METHODS The expressions of Aurora A mRNA and protein in prostate cancer tissue and cell line were measured using RT-PCR, immunohistochemistry and Western blot analyses. Meanwhile, A DNAzyme targeting at Aurora A mRNA was performed to detect the inhibition effect of Aurora A in regulating the growth of prostate cancer cell line PC3. RESULTS Aurora A expression was up-regulated in 91% prostate cancer tissue as well as in prostate cancer cell lines such as PC3, LNCaP and Du145. Furthermore, Aurora A expression suppressed by cell transduction of a DNAzyme targeting at Aurora A mRNA made the PC3 cells both arrest the cell cycle in G2/M phase and increase the cell apoptosis. CONCLUSIONS These findings suggest that Aurora A up-regulation may be involved in carcinogenesis of prostate cancer, and that aurora A gene may be a valuable target for treatment of prostate cancer." @default.
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- W2379728446 date "2008-01-01" @default.
- W2379728446 modified "2023-09-23" @default.
- W2379728446 title "Effect of aurora A on carcinogenesis of human prostate cancer" @default.
- W2379728446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18390187" @default.
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