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- W2379732306 abstract "OBJECTIVE: To discuss whether the dexamethason can induce cisplatin resistance in lung cancer cells.METHODS: The lung cancer cell line A1 and the lung cancer cells isolated from resected lung cancer cell samples of 26 patients with lung cancer were pre-cultured in vitro for 24 h with dexamethason in different concentration and then cisplatin was added and the cells were cultured for another 48 h, with the survival rates of the cells determined by MTT method.RESULTS: A1 cells showed cisplatin resistance when pre-cultured with dexamethason and the resistance intensity was dexamethason concentration-dependent.Cisplatin resistance was noted in the lung cancer cells of 1 male patient(1/26,3.8%) and 4 female patients(4/26,15.4%),showing signficant difference between male and female cases(P0.01).CONCLUSION: The in vitro study shows that dexamethason doesn't induce cisplatin resistance of lung tumor cells in most patients with lung cancer,and the rate of cisplatin resistance induced by dexamethason is higher in female cases than in male cases." @default.
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- W2379732306 date "2008-01-01" @default.
- W2379732306 modified "2023-09-25" @default.
- W2379732306 title "Dexamethasone-induced Cisplatin Resistance in Lung Cancer Cells and Its Sex Differences" @default.
- W2379732306 hasPublicationYear "2008" @default.
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