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- W2379737112 abstract "Objective: To investigate the effect of connective tissue growth factor(CTGF) on the proliferation in human pancreatic cancer cell line SW1990,with a focus on the expression of matrix metalloproteinase-9(MMP-9) and vascular endothelial growth factor(VEGF).This study was designed to explore the underlying mechanism for the role of CTGF in the development of pancreatic cancer.Methods: pcDNA3.0CTGF and pcDNA3.0 were transfected into SW1990 cells through lipofectamine and positive clones were screened by G418.RT-PCR and Western blotting were employed to identify mRNA and protein expression of CTGF in SW1990 cells,respectively.The expression of MMP-9 and VEGF in positive clones was detected by RT-PCR and Western blotting.Cell viability was assessed by dimethylthiazol diphenyl tetrazoliumbromide(MTT) method.Results: Positive clones C-5 and C-28 with CTGF over-expression were successfully established.Compared with non-transfected control group,the expressions of MMP-9 and VEGF in C-5 and C-28 was increased significantly,and the proliferation level of C-5 and C-28 was increased significantly.Conclusions: CTGF transfection could effectively enhance the expression of MMP-9 and VEGF and the proliferation in SW1990 cells which suggested a potential role for CTGF in gene therapy of pancreatic cancer." @default.
- W2379737112 created "2016-06-24" @default.
- W2379737112 creator A5035822280 @default.
- W2379737112 date "2013-01-01" @default.
- W2379737112 modified "2023-09-23" @default.
- W2379737112 title "Effect of gene CTGF transfection on the expression of MMP-9 and VEGF and proliferation in human pancreatic cancer cells" @default.
- W2379737112 hasPublicationYear "2013" @default.
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