Matches in SemOpenAlex for { <https://semopenalex.org/work/W2379751799> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2379751799 abstract "Objective To explore the toxical action of(L-) pantoprazole sodium in the animals and to provide the dose to clinical research.Method Take mice,rats and Beagle dogs as the research objects,and observe the toxical reaction of(L-) pantoprazole sodium in the animals above.Hematology such as red blood cell(RBC),white blood cell(WBC) and blood biochemical parameters were analyzed.The important target organs(heart,kidney,brain and liver) were observed and measured by eye.Results The lethal dose(LD) of(L-) pantoprazole sodium for mice was 381.52mg/kg.When the Beagle dogs were injected with(L-) pantoprazole sodium in the dose of 150 mg / kg,the acute toxic reactions were body shaking,excessive flow of saliva,paralyzed,and vomiting,then died in 20 min later.The chronic toxic reaction of(L-) pantoprazole sodium at high,medium,and low doses(10,30,and 90 mg / kg) by iv gtt for 31 days in the rats,and the ALT,AST were raised,their quantity of food and body weight were decreased.Conclusion The lethal dose(LD) of(L-) pantoprazole sodium for mice was 381.52mg/kg.At the dose of 67 mg/kg,the Beagles showed a degree of toxic reaction,the acute reaction of the chemical was related to nervous system,and no organ was obviously hurt.(L-) pantoprazole sodium(90 mg/kg)can decrease the WBC and RBC,increase plasma AST,ALT,CHOL in rats when it is used in long term." @default.
- W2379751799 created "2016-06-24" @default.
- W2379751799 creator A5012645485 @default.
- W2379751799 date "2012-01-01" @default.
- W2379751799 modified "2023-09-24" @default.
- W2379751799 title "Preclinical Toxicologic Studies of (L-)pantoprazole Sodium" @default.
- W2379751799 hasPublicationYear "2012" @default.
- W2379751799 type Work @default.
- W2379751799 sameAs 2379751799 @default.
- W2379751799 citedByCount "0" @default.
- W2379751799 crossrefType "journal-article" @default.
- W2379751799 hasAuthorship W2379751799A5012645485 @default.
- W2379751799 hasConcept C126322002 @default.
- W2379751799 hasConcept C134018914 @default.
- W2379751799 hasConcept C178790620 @default.
- W2379751799 hasConcept C185592680 @default.
- W2379751799 hasConcept C2776820430 @default.
- W2379751799 hasConcept C2777498785 @default.
- W2379751799 hasConcept C2781315423 @default.
- W2379751799 hasConcept C537181965 @default.
- W2379751799 hasConcept C71924100 @default.
- W2379751799 hasConcept C98274493 @default.
- W2379751799 hasConceptScore W2379751799C126322002 @default.
- W2379751799 hasConceptScore W2379751799C134018914 @default.
- W2379751799 hasConceptScore W2379751799C178790620 @default.
- W2379751799 hasConceptScore W2379751799C185592680 @default.
- W2379751799 hasConceptScore W2379751799C2776820430 @default.
- W2379751799 hasConceptScore W2379751799C2777498785 @default.
- W2379751799 hasConceptScore W2379751799C2781315423 @default.
- W2379751799 hasConceptScore W2379751799C537181965 @default.
- W2379751799 hasConceptScore W2379751799C71924100 @default.
- W2379751799 hasConceptScore W2379751799C98274493 @default.
- W2379751799 hasLocation W23797517991 @default.
- W2379751799 hasOpenAccess W2379751799 @default.
- W2379751799 hasPrimaryLocation W23797517991 @default.
- W2379751799 hasRelatedWork W2006661975 @default.
- W2379751799 hasRelatedWork W2017542338 @default.
- W2379751799 hasRelatedWork W2035150171 @default.
- W2379751799 hasRelatedWork W2058495944 @default.
- W2379751799 hasRelatedWork W2082122957 @default.
- W2379751799 hasRelatedWork W2085444653 @default.
- W2379751799 hasRelatedWork W2090514176 @default.
- W2379751799 hasRelatedWork W2188000225 @default.
- W2379751799 hasRelatedWork W2321897891 @default.
- W2379751799 hasRelatedWork W2353625213 @default.
- W2379751799 hasRelatedWork W2367465747 @default.
- W2379751799 hasRelatedWork W2378642626 @default.
- W2379751799 hasRelatedWork W2379468431 @default.
- W2379751799 hasRelatedWork W2393087683 @default.
- W2379751799 hasRelatedWork W2397600134 @default.
- W2379751799 hasRelatedWork W2415434371 @default.
- W2379751799 hasRelatedWork W2785915477 @default.
- W2379751799 hasRelatedWork W2958568246 @default.
- W2379751799 hasRelatedWork W2980935733 @default.
- W2379751799 hasRelatedWork W58133657 @default.
- W2379751799 isParatext "false" @default.
- W2379751799 isRetracted "false" @default.
- W2379751799 magId "2379751799" @default.
- W2379751799 workType "article" @default.