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- W2379752069 abstract "Objective To study the effect of Matrine on TNF-α during cold preservation and reperfusion injury in rat orthotopic liver transplantation(OLT).Methods 168 syngeneic SD rats were randomly divided into four groups:untreated group,matrine 40mg/kg treated group,matrine 80mg/kg treated group and sham operation group.After 5 hours of preservation in Ringer's(LR) solution,orthotopic implantation of the donor liver was performed.At 1h,2h,4h and 24h after reperfusion of the protal vein,6 rats were killed in each group to collect the serum and the median lobe of liver for assay.Result Matrine markedly inhibited the activation of Kupffer cells and the release of tumor necrosis factor(TNF) at different times post-transplantation.The level of hyaluronic acid(HA) and glutamatepyruvate transaminase(ALT) also decreased significantly in both groups treated with matrine.The pathological injury of hepatocyted and sinusoidal endothelial cells(SEC) were ameliorated,too.Conclusion Matrine can decrease the TNF-α level and prevent donor liver from cold preservation and reperfusion injury in rat orthotopic liver transplantation." @default.
- W2379752069 created "2016-06-24" @default.
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- W2379752069 date "2005-01-01" @default.
- W2379752069 modified "2023-09-24" @default.
- W2379752069 title "EFFECT OF MATRINE ON TNF-α DURING COLD PRESERVATION AND REPERFUSION INJURY IN RAT ORTHOTOPIC LIVER TRANSPLANTATION" @default.
- W2379752069 hasPublicationYear "2005" @default.
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