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- W2379772212 abstract "Objective To explore the application of multifactor dimensionality reduction(MDR) in the risk assessment of inflammatory cytokine gene(interleukin-1,tumor necrosis factor and macrophage migration inhibitory factor)-environment interaction in gastric cancer research.Methods The MDR software was applied to analyze gene-environment interaction on the risk of gastric cancer susceptibility,while the results of logistic regression was analysed as supplement.Results The interaction among IL-1B-511,IL-1RN,TNF-A-308 genotypes and tumor familial history made the best MDR model with a statistical significance(P 0.01).Testing balance accuracy of this model was 0.72 and the cross-validation consistency was 10/10.The research subjects were divided into high-risk and low-risk groups according to this model.The estimated odds ratio(OR) value of interaction effects on gastric cancer was 13.49(95%confidence interval :8.62-21.10) with a statistical significance(P0.01).There were significant differences among group 1(one factor),group 2(two factors) and group 3(three factors)(P0.05) with the OR values of 2.17,11.61,and 27.19.Conclusion The interaction of IL-1B-511,IL-1RN,TNF-A-308 and tumor familial history may increase the risk of gastric cancer." @default.
- W2379772212 created "2016-06-24" @default.
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- W2379772212 date "2013-01-01" @default.
- W2379772212 modified "2023-09-23" @default.
- W2379772212 title "Inflammatory cytokine gene-environment interaction on risk of gastric cancer susceptibility" @default.
- W2379772212 hasPublicationYear "2013" @default.
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