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- W2379780523 abstract "AIM:To investigate the effect of glucose control with insulin on myocardial ischemia/reperfusion(MI/R) in streptozotocin(STZ)-induced diabetic mice.METHODS:Type 1 diabetes was induced by i.p.injection of STZ and was treated with insulin for 2 weeks.Mice were divided into four groups:sham group,I/R group,DM+I/R group,and DM+insulin+I/R group.Myocardial ischemia was produced by temporarily exteriorizing the heart via a left thoracic incision and placing a 6-0 silk suture slipknot around the left anterior descending coronary artery.After 30 min of ischemia,the slipknot was released and the myocardium was reperfused for 3 h(for caspase-3 activity and nitrotyrosine contents by ELISA,apoptosis by TUNEL) or 24 h(for infarct size by TTC staining).RESULTS:Compared with those in I/R group,infarct size,myocardial apoptosis,caspase-3 activity and nitrotyrosine contents increased in DM+I/R group(P0.01).Compared with those in DM+I/R group,myocardial apoptosis(P0.01),infarct size,caspase-3 activity and nitrotyrosine contents(P0.05) were reduced in DM+insulin+I/R group.CONCLUSION:Type 1 diabetes aggravates MI/R injury and glucose control with insulin attenuates MI/R injury in STZ-induced diabetic mice." @default.
- W2379780523 created "2016-06-24" @default.
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- W2379780523 date "2011-01-01" @default.
- W2379780523 modified "2023-09-23" @default.
- W2379780523 title "Glucose control with insulin attenuates myocardial ischemia/reperfusion injury in mice with type 1 diabetes" @default.
- W2379780523 hasPublicationYear "2011" @default.
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