Matches in SemOpenAlex for { <https://semopenalex.org/work/W2379787712> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2379787712 abstract "AIM:To study the molecular mechanisms of liver regeneration following different cold ischemia(CI)times after liver transplantation in a rat model.METHODS:A model of rat orthotopic liver transplantation was established.The rats were divided into 3 groups:1 h CI group,8 h CI group and 16 h CI group.Survival rate in each group was recorded.Specimen were collected at predetermined intervals from 90 min,1,4 and 7 d post-reperfusion.The patterns of TNF-α,IL-6 and STAT3 activation were determined in liver grafts with 1 h,8 h and 16 h CI times.Expression of cyclin D1 and hepatocyte replication with bromodeoxyuridine(BrdU)were confirmed by immunohistochemistry.The results of TNF-α and IL-6 expression in all groups were analyzed after whole liver transplantation.Statistical analysis was used to compare BrdU positively stained hepatocytes at 48 h post-reperfusion.RESULTS:Liver transplantation was successfully performed in all experimental groups.Survival rate in each group was 100%(14 d).Compared with 1 h CI,TNF-α expressions in whole liver grafts with 8 h and 16 h CI were markedly increased at 90 min after reperfusion(P0.05).Compared with 1 and 8 h CI,IL-6 expression in liver grafts preserved for 16 h were markedly increased at 90 min after transplantation(P0.05).With 8 and 16 h CI,STAT3 activity was markedly increased.Cyclin D1 expression in 8 CI group was demonstrated with cytoplasmic and nuclear staining at 24 h in liver grafts.Cyclin D1 expression was mainly nuclear in 16 h CI group.Extensive hepatocyte replication was present.The numbers of hepatocytes with positively stained nuclei in 16 h CI group were more than those in 1 and 8 h CI group at 48 h after transplantation(P0.05).CONCLUSION:Rat whole liver grafts with 16 h CI injury still initiate and complete liver regeneration and graft recovery after liver transplantation.Liver regeneration following transplantation may be through TNF-α/IL-6/STAT3/cyclin D1/DNA synthesis pathways." @default.
- W2379787712 created "2016-06-24" @default.
- W2379787712 creator A5007158359 @default.
- W2379787712 creator A5019115888 @default.
- W2379787712 creator A5084143984 @default.
- W2379787712 date "2000-01-01" @default.
- W2379787712 modified "2023-09-24" @default.
- W2379787712 title "Molecular mechanisms of liver regeneration following cold ischemia injury after liver transplantation in rat" @default.
- W2379787712 hasPublicationYear "2000" @default.
- W2379787712 type Work @default.
- W2379787712 sameAs 2379787712 @default.
- W2379787712 citedByCount "0" @default.
- W2379787712 crossrefType "journal-article" @default.
- W2379787712 hasAuthorship W2379787712A5007158359 @default.
- W2379787712 hasAuthorship W2379787712A5019115888 @default.
- W2379787712 hasAuthorship W2379787712A5084143984 @default.
- W2379787712 hasConcept C121608353 @default.
- W2379787712 hasConcept C126322002 @default.
- W2379787712 hasConcept C134018914 @default.
- W2379787712 hasConcept C142724271 @default.
- W2379787712 hasConcept C16685009 @default.
- W2379787712 hasConcept C171056886 @default.
- W2379787712 hasConcept C199835354 @default.
- W2379787712 hasConcept C202751555 @default.
- W2379787712 hasConcept C204232928 @default.
- W2379787712 hasConcept C2776200302 @default.
- W2379787712 hasConcept C2776795407 @default.
- W2379787712 hasConcept C2778260397 @default.
- W2379787712 hasConcept C2779609443 @default.
- W2379787712 hasConcept C2780114680 @default.
- W2379787712 hasConcept C2911091166 @default.
- W2379787712 hasConcept C29537977 @default.
- W2379787712 hasConcept C541997718 @default.
- W2379787712 hasConcept C55493867 @default.
- W2379787712 hasConcept C71924100 @default.
- W2379787712 hasConcept C86803240 @default.
- W2379787712 hasConcept C95444343 @default.
- W2379787712 hasConceptScore W2379787712C121608353 @default.
- W2379787712 hasConceptScore W2379787712C126322002 @default.
- W2379787712 hasConceptScore W2379787712C134018914 @default.
- W2379787712 hasConceptScore W2379787712C142724271 @default.
- W2379787712 hasConceptScore W2379787712C16685009 @default.
- W2379787712 hasConceptScore W2379787712C171056886 @default.
- W2379787712 hasConceptScore W2379787712C199835354 @default.
- W2379787712 hasConceptScore W2379787712C202751555 @default.
- W2379787712 hasConceptScore W2379787712C204232928 @default.
- W2379787712 hasConceptScore W2379787712C2776200302 @default.
- W2379787712 hasConceptScore W2379787712C2776795407 @default.
- W2379787712 hasConceptScore W2379787712C2778260397 @default.
- W2379787712 hasConceptScore W2379787712C2779609443 @default.
- W2379787712 hasConceptScore W2379787712C2780114680 @default.
- W2379787712 hasConceptScore W2379787712C2911091166 @default.
- W2379787712 hasConceptScore W2379787712C29537977 @default.
- W2379787712 hasConceptScore W2379787712C541997718 @default.
- W2379787712 hasConceptScore W2379787712C55493867 @default.
- W2379787712 hasConceptScore W2379787712C71924100 @default.
- W2379787712 hasConceptScore W2379787712C86803240 @default.
- W2379787712 hasConceptScore W2379787712C95444343 @default.
- W2379787712 hasIssue "08" @default.
- W2379787712 hasLocation W23797877121 @default.
- W2379787712 hasOpenAccess W2379787712 @default.
- W2379787712 hasPrimaryLocation W23797877121 @default.
- W2379787712 hasRelatedWork W175382700 @default.
- W2379787712 hasRelatedWork W1987650345 @default.
- W2379787712 hasRelatedWork W2025332498 @default.
- W2379787712 hasRelatedWork W2353293080 @default.
- W2379787712 hasRelatedWork W2357236579 @default.
- W2379787712 hasRelatedWork W2357840050 @default.
- W2379787712 hasRelatedWork W2360389482 @default.
- W2379787712 hasRelatedWork W2362755870 @default.
- W2379787712 hasRelatedWork W2366746283 @default.
- W2379787712 hasRelatedWork W2366890343 @default.
- W2379787712 hasRelatedWork W2372001958 @default.
- W2379787712 hasRelatedWork W2377653619 @default.
- W2379787712 hasRelatedWork W2382812734 @default.
- W2379787712 hasRelatedWork W2386258427 @default.
- W2379787712 hasRelatedWork W2391541481 @default.
- W2379787712 hasRelatedWork W2392001150 @default.
- W2379787712 hasRelatedWork W2462534876 @default.
- W2379787712 hasRelatedWork W3031766679 @default.
- W2379787712 hasRelatedWork W3031985841 @default.
- W2379787712 hasRelatedWork W3032394812 @default.
- W2379787712 isParatext "false" @default.
- W2379787712 isRetracted "false" @default.
- W2379787712 magId "2379787712" @default.
- W2379787712 workType "article" @default.