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- W2379798423 abstract "Objective To evaluate the effect of PECAM1/CD31(platelet endothedial cell adhesion molecule-1) in ischemia-reperfusion induced pulmonary injury of rats. Methods Single lung in situ warm ischemia-reperfusion animal model was established,and SD rats were divided into the control group and test group(ischemia-reperfusion).The rats was subjected to 60 min lung ischemia followed by 0,2,4,6 or 8 h of reperfusion separately.At the end of reperfusion,expression of PECAM-1/CD31 in neutrophilic granulocytes and lymphocytes from blood was detected by using FCM method.Histology of lung,morphology and ultrastructural changes of cells were examined by microscope and transmission electron microscope to determine apoptosis. Results PECAM-1/CD31 expression started to increase after reperfusion,peaked at tie 2 h(P0.01)after reperfusion and then gradually decreased to basal level at the 6 and 8 h.Proliferation of alveolar type Ⅱendothelial cells,accompanied by ultrastructural morphological changes were observed after reperfusion.Moreover,the membrane microvilli decreased and even disappeared,apoptotic body was also found,which suggested apoptosis formed.This ultrastructural change was prominent at 2 h after reperfusion,which was similar to the change of PECAM-1. Conclusion PECAM-1/CD31 may involve in and mediate the ischemia-reperfusion induced pulmonary injury,which can be used as the marker molecule for the latter." @default.
- W2379798423 created "2016-06-24" @default.
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- W2379798423 date "2007-01-01" @default.
- W2379798423 modified "2023-09-23" @default.
- W2379798423 title "Effect of Platelet Endothedial Cell Adhesion Molecule-1 in Ischemia-reperfusion Induced Pulmonary Injury: An Experimental Study on Rats" @default.
- W2379798423 hasPublicationYear "2007" @default.
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