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- W2379807881 abstract "AIM To investigate the protective effects and mechanisms of TMP on accelerated anti-glomerulus basement membrane(GBM) antibody nephritis of rats. METHODS Model of accelerated anti-GBM nephritis was established in rats and TMP was administrated 120 mg·kg -1 ·d -1 by ip since the day before the model established, consecutively for 15 days. Content of 24h urine protein was detected after model established and rats were killed on d 7 and d 14. Contents of blood urine nitrogen (BUN) and serum creatinine (SCr) were detected. Renal cortex cytoplasm and mitochondria were produced and change of content of lipid peroxidation products malondialdehyde(MDA), activities of glutathione peroxidase(GSH-Px) and catalase(CAT) and superoxide dismutase(SOD) were investigated. RESULTS Compared with model group, TMP group showed significant inhibition in changes of proteinuria and BUN, SCr(P0.01) on d 14 and significant increase in activity of GSH-Px, Cat, SOD (P0.05,P0.01), while content of MDA decreased in both cytoplasm and mitochondria(P0.05). CONCLUSION TMP has protective effects against accelerated anti-GBM antibody nephritis in rats via anti-oxidation activity.-" @default.
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- W2379807881 date "2004-01-01" @default.
- W2379807881 modified "2023-09-25" @default.
- W2379807881 title "Protective effects and mechanisms of tetramethypyrazine on accelerated anti-GBM antibody nephritis in rats" @default.
- W2379807881 hasPublicationYear "2004" @default.
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