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- W2379812393 abstract "To investigate the changes in heme oxygenase (HO) carbon monoxide (CO) cyclic guanosine monophosphate (cGMP) pathway in calcified rat vascular smooth muscle cells (VSMCs). Calcification of cultured rat VSMCs was induced by incubation of VSMCs with β glycerophosphate. Cellular calcium content, ALP activity and 45 Ca deposition were measured. HO activity, HbCO formation and content of cGMP in VSMCs were determined. Immunocytochemistry pictures for HO 1 expression were observed. In comparison to control VSMCs the cellular calcium content, ALP activity and 45 Ca deposition in calcified VSMCs obviously increased. Immunocytochemistry observation showed that HO 1 expression was weak and not well distributed in calcified cells as compared to non calcified VSMCs, but there was heavier staining in calcified nodules than in VSMCs. Compared with VSMCs, HO 1 activity in calcified cells decreased by 42.7%(36.4±2.8 pmol/mg protein·h vs 63.5±5.3 pmol/(mg protein·h), P 0.01), and HbCO formation decreased by 39.2% (3.38±0.69 μmol/ mg protein vs 5.56±0.48 μmol/mg protein, P 0.05). cGMP content in calcified VSMCs was 78.1% lower than that of non calcified VSMCs (4.3±0.5 vs 19.6±1.2 pmol/mg protein, P 0.01). The results showed that HO CO cGMP pathway in calcified vascular cells underwent a significant change, which might contribute to the disturbance of vascular function." @default.
- W2379812393 created "2016-06-24" @default.
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- W2379812393 date "2003-01-01" @default.
- W2379812393 modified "2023-09-25" @default.
- W2379812393 title "Changes in heme-oxygenase and carbon monoxide-cGMP pathway in calcified rat vascular smooth muscle cells" @default.
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