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- W2379819272 abstract "Objective To explore nestin expression in human thyroid neoplasms and non-tumorous thyroid tissues.Methods Eighty-one thyroid tissue blocks from 25 patients with papillary carcinoma(PTC),25 patients with adenoma,19 patients with nodular goiter and 12 normal thyroid tissues from surrounding tissue of surgically removed adenoma were used to detect nestin protein expression by immunohistochemistry(IHC) technique and nestin RNA expression by laser capture microdissection(LCM) technique and RT-PCR.Results The positive signal of IHC was mostly from follicular epithelial cells in papillary carcinoma and adenoma tissues.The detected positive rates of nestin in papillary carcinoma and adenoma tissues were 56.0%(14/25) and 32.0%(8/25),respectively.In both multinodular goiters and normal tissues,the positive rates were 0.Statistical analysis indicated that nestin expression was significantly different between the non-tumorous thyroid tissues and neoplasms(χ2=14.267,P=0.000).Conclusions Immunohistochemical staining for nestin may be useful for the differential diagnosis between the common thyroid tumors and multinodular goiter and normal tissues but the mechanism of nestin expression frequently in thyroid tumors remains unclear." @default.
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- W2379819272 date "2010-01-01" @default.
- W2379819272 modified "2023-09-22" @default.
- W2379819272 title "Nestin expression frequently occurs in human thyroid tumors" @default.
- W2379819272 hasPublicationYear "2010" @default.
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