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- W2379825438 abstract "Objective: To analyze the origin and variation of bacterial endotoxin in meningococcal conjugate vaccines by determining its contents in the intermediate products at different manufacturing stages by bacterial endotoxin test,thus providing experiment basis for control of bacterial endotoxin. Methods: Bacterial endotoxin test included in Chinese Pharmacopoeia Volume Ⅲ( 2010 Edition) was adopted to determine the contents of bacterial endotoxin in the intermediate and final products of meningococcal conjugate vaccines on the basis of sample dilution test and standardization of the method. Results: The principal origins of bacterial endotoxin in meningococcal conjugate vaccines were the manufacturing materials,i. e. meningococcal polysaccharides or carrier proteins,and the content of bacterial endotoxin could be well controlled during the preparation process. Conclusion: The content of bacterial endotoxin in meningococcal conjugate vaccines may be efficiently restrained or even lowered during the production process by optimizing the purification techniques for both of meningococcal polysaccharide and carrier proteins in order to improve the safety of the vaccines." @default.
- W2379825438 created "2016-06-24" @default.
- W2379825438 creator A5018492075 @default.
- W2379825438 date "2014-01-01" @default.
- W2379825438 modified "2023-09-23" @default.
- W2379825438 title "Assay of bacterial endotoxin in meningococcal conjugate vaccines during different preparation stages" @default.
- W2379825438 hasPublicationYear "2014" @default.
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