FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2379836711> ?p ?o ?g. }

• W2379836711 abstract "Objective To further evaluate the efficacy and safety of total glucosides palony (TGP) as a DMARD in the treatment of rheumatoid arthritis (RA). Methods Three hundred and seventy cases of RA were randomly divided into five groups: MTX, MTX plus TGP, MTX plus SSZ, TGP plus SSZ, and TGP group in a randomized, 24~48 week open trial. The registered indexes included joint pain, number and index of joint tenderness and joint swelling, duration of morning stiffness, grip strength, joint function status, ESR, CRP and RF. Results After 24 weeks of treatment, the clinical items improvement was similar among five groups except the index of joint swelling in TGP plus MTX group and morning stiffness in MTX group was better than that of the other groups. After 36 weeks the efficacy was better than other groups in 4 items for MTX group, 3 items for TGP+SSZ and 2 items for MTX plus SSZ and TGP groups. Efficacy was worse than other groups in 3 items for TGP plus MTX group. After 48 weeks, the efficacy was better than other groups in 5 items for MTX group, 3 items for TGP group, 2 items for MTX plus SSZ and TGP plus SSZ group. Meanwhile the efficacy was not as good as other groups in 3 items in TGP plus MTX group and one parameter in TGP plus SSZ and TGP group. ESR declined significantly after 24 and 48 weeks, CRP was decreased with similar pattern except for MTX plus TGP group. RF was invariable in TGP group after treatment for 24 and 48 weeks. MTX and TGP plus MTX group were more effective in RF reduction than TGP plus SSZ group and MTX plus SSZ group. TGP had an advantage in the improvement of joint function and later onset of effect than MTX. The primary side-effect for TGP was diarrhea/constipation with no severe adverse events happened in all groups. No other side-effect was observed in 48 weeks. Conclusion TGP, TGP combined with MTX or with SSZ may have an equivalent effect to MTX and MTX plus SSZ. It suggests that TGP may be an effective drug for RA with less side-effects and good safety." @default.
• W2379836711 created "2016-06-24" @default.
• W2379836711 creator A5081651341 @default.
• W2379836711 date "2005-01-01" @default.
• W2379836711 modified "2023-09-25" @default.
• W2379836711 title "A clinical study of total glucosides palony in the treatment of rheumatoid arthritis: a multi-center trial" @default.
• W2379836711 hasPublicationYear "2005" @default.
• W2379836711 type Work @default.
• W2379836711 sameAs 2379836711 @default.
• W2379836711 citedByCount "0" @default.
• W2379836711 crossrefType "journal-article" @default.
• W2379836711 hasAuthorship W2379836711A5081651341 @default.
• W2379836711 hasConcept C126322002 @default.
• W2379836711 hasConcept C141071460 @default.
• W2379836711 hasConcept C168563851 @default.
• W2379836711 hasConcept C19720800 @default.
• W2379836711 hasConcept C2776260265 @default.
• W2379836711 hasConcept C2777077863 @default.
• W2379836711 hasConcept C2777433710 @default.
• W2379836711 hasConcept C2777575956 @default.
• W2379836711 hasConcept C2777785397 @default.
• W2379836711 hasConcept C2909196033 @default.
• W2379836711 hasConcept C71924100 @default.
• W2379836711 hasConcept C90924648 @default.
• W2379836711 hasConceptScore W2379836711C126322002 @default.
• W2379836711 hasConceptScore W2379836711C141071460 @default.
• W2379836711 hasConceptScore W2379836711C168563851 @default.
• W2379836711 hasConceptScore W2379836711C19720800 @default.
• W2379836711 hasConceptScore W2379836711C2776260265 @default.
• W2379836711 hasConceptScore W2379836711C2777077863 @default.
• W2379836711 hasConceptScore W2379836711C2777433710 @default.
• W2379836711 hasConceptScore W2379836711C2777575956 @default.
• W2379836711 hasConceptScore W2379836711C2777785397 @default.
• W2379836711 hasConceptScore W2379836711C2909196033 @default.
• W2379836711 hasConceptScore W2379836711C71924100 @default.
• W2379836711 hasConceptScore W2379836711C90924648 @default.
• W2379836711 hasLocation W23798367111 @default.
• W2379836711 hasOpenAccess W2379836711 @default.
• W2379836711 hasPrimaryLocation W23798367111 @default.
• W2379836711 hasRelatedWork W1020987747 @default.
• W2379836711 hasRelatedWork W1942301967 @default.
• W2379836711 hasRelatedWork W1996437423 @default.
• W2379836711 hasRelatedWork W2096886481 @default.
• W2379836711 hasRelatedWork W2105500082 @default.
• W2379836711 hasRelatedWork W2143972196 @default.
• W2379836711 hasRelatedWork W2322293030 @default.
• W2379836711 hasRelatedWork W2353466245 @default.
• W2379836711 hasRelatedWork W2358145120 @default.
• W2379836711 hasRelatedWork W2362450088 @default.
• W2379836711 hasRelatedWork W2366996689 @default.
• W2379836711 hasRelatedWork W2373629820 @default.
• W2379836711 hasRelatedWork W2374046125 @default.
• W2379836711 hasRelatedWork W2375363171 @default.
• W2379836711 hasRelatedWork W2377510725 @default.
• W2379836711 hasRelatedWork W2379591930 @default.
• W2379836711 hasRelatedWork W2385166155 @default.
• W2379836711 hasRelatedWork W2385808951 @default.
• W2379836711 hasRelatedWork W2394920829 @default.
• W2379836711 hasRelatedWork W765976976 @default.
• W2379836711 isParatext "false" @default.
• W2379836711 isRetracted "false" @default.
• W2379836711 magId "2379836711" @default.
• W2379836711 workType "article" @default.