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• W2379852144 abstract "In order to interact with the egg and undergo acrosomal exocytosis or the acrosome reaction (AR), mammalian spermatozoa must undergo a series of biochemical changes in the female reproductive tract, collectively called capacitation. We showed that F-actin is formed during sperm capacitation and fast depolymerization occurs prior to the AR. We hypothesized that F-actin protects the sperm from undergoing spontaneous-AR (sAR) which decreases fertilization rate. We show that activation of the actin-severing protein gelsolin induces a significant increase in sAR. Moreover, inhibition of CaMKII or PLD during sperm capacitation, caused an increase in sAR and inhibition of F-actin formation. Spermine, which leads to PLD activation, was able to reverse the effects of CaMKII inhibition on sAR-increase and F-actin-decrease. Furthermore, the increase in sAR and the decrease in F-actin caused by the inactivation of the PLD-pathway, were reversed by activation of CaMKII using H2O2 or by inhibiting protein phosphatase 1 which enhance the phosphorylation and oxidation states of CaMKII. These results indicate that two distinct pathways lead to F-actin formation in the sperm capacitation process which prevents the occurrence of sAR." @default.
• W2379852144 created "2016-06-24" @default.
• W2379852144 creator A5020421724 @default.
• W2379852144 creator A5046615745 @default.
• W2379852144 date "2016-07-01" @default.
• W2379852144 modified "2023-10-16" @default.
• W2379852144 title "CaMKII prevents spontaneous acrosomal exocytosis in sperm through induction of actin polymerization" @default.
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• W2379852144 doi "https://doi.org/10.1016/j.ydbio.2016.05.008" @default.
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