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• W2379859943 abstract "Background and purpose:Intensity modulated radiation therapy(IMRT) is now widely used in the radiation therapy of nasopharyngeal carcinoma, but more accurate positioning of patients is required as compared to conventional radiotherapy. The purpose of this study was to determine the impact of dose delivery errors that could result from systematic setup errors for IMRT of nasopharyngeal carcinoma on the dose distribution affecting Dimensional conformal radiotherapy(DCRT) treatments according to simulated systematic setup errors by moving the isocenter. Methods:Eight patients with IMRT and DCRT plan were evaluated to assess the impact of systematic setup errors. The dosimetric effect of systematic error was simulated by randomly shifting the patient isocenter along each of the three Cartesian axes, with each shift selected from a normal distribution. Systematic setup error of 2 mm and 5 mm were simulated. For each dose calculation, we analyzed the ratio of each dose evaluation index to the normal plan used for real time treatment and compared the sensitivity of DCRT and IMRT to setup errors. Results:Frequency distribution showed that simulating systematic setup error with 5 mm resulted in 4.2% of GTV98 and 12.5% of CTV95 with the dose reduction of more than 3%, whereas simulating systematic setup error with 2 mm resulted in having no more than 3% dose error in IMRT. For DCRT, neither simulated systematic error with 5 mm nor with 2 mm resulted in having more than 3% dose error. With 5 mm systematic setup error, the dose of critical organs increased with 10.4% for spinal cord, 14.6% for brain stem, 31.2% for left parotid and 25% for right parotid with more than 10% dose distribution different from real time treatment planning, and with 2 mm systematic setup error, the dose of critical organs increased only with 6.3% for spinal cord, 4.2% for brain stem, there were more than 5% dose distribution difference, 12.5% for left parotid and 8.3% right parotid with more than 10% dose distribution different from real time treatment. However, in DCRT with 5mm systematic setup error, only 10.4% for spinal cord, 6.3% for brain stem were documented with more than 5% dose distribution different from real time treatment, there was no significant increase in the dose of left parotid and right parotid. For both targets and critical organs, comparing IMRT with DCRT, the mean percent dose change of the simulated structure dose in terms of the normal plan was more sensitive to IMRT(P0.05). the higher the systematic setup error, the more significant the impact on dose distribution(P0.05). Conclusions:The higher systematic setup error induced more significant dose error. For both targets and critical organs, IMRT was more sensitive to systematic setup error than DCRT. For IMRT, GTV was more sensitive to patient positioning than CTV and parotids were more sensitive to patient positioning than spinal cord and brain stem." @default.
• W2379859943 created "2016-06-24" @default.
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• W2379859943 date "2008-01-01" @default.
• W2379859943 modified "2023-09-22" @default.
• W2379859943 title "Systematic setup errors for intensity modulated radiation therapy in the nasopharyngeal carcinoma:effect on dose distribution" @default.
• W2379859943 hasPublicationYear "2008" @default.
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