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- W2379860949 abstract "Objective:To study the effects of docetaxel on moderately differentiated stomach carcinoma SGC-7901 cells and the corresponding mechanism. Methods:The inhibitory effect of docetaxel on the growth of SGC-7901 cells was detected by MTT assay. Annexin-V kit was used to test the early apoptosis of SGC-7901 cells induced by docetaxel. The late apoptotic cells were assessed by propidium iodide (PI) staining. Flow cytometry was employed to measure the changes of expression of apoptosis-related molecules such as Fas protein and Bcl-2 protein after treatment with docetaxel. Results: The growth inhibitory rate of SGC-7901 cells was 13.3%,21.6%,57.5%,and 61.0%, after treatment with docetaxel at different concentrations of 0.92,3.7, 14.8,and 59.2 μg/mL for 72 h, respectively. Docetaxel induced apoptosis of SGC-7901 cells. The expression of Fas molecule was enhanced by docetaxel in SGC-7901 cells (26.5%±7.2% vs 37.9%±7.0%); while the expression of Bcl-2 did not change significantly (38.9%±9.1% vs 31.2%±5.6%). Conclusion:Docetaxel had significant inhibitory effects on the proliferation of SGC-7901 cells. Docetaxel induced apoptosis of SGC-7901 cells, which maybe attributed to the enhanced expression of Fas molecule induced by docetaxel." @default.
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- W2379860949 date "2006-01-01" @default.
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- W2379860949 title "Effect of docetaxel on gastric cancer cells and its mechanism" @default.
- W2379860949 hasPublicationYear "2006" @default.
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