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- W2379864786 abstract "AIM To investigate the effect of mipafox that induced delayed neuropathy on neural differentiation in human neuroblastoma SK-N-SH cells and elucidate its mechanism. METHODS Inhibitory effects of mipafox(50 μmol·L~ -1 ) and paraoxon(50 μmol·L~ -1 ) on cell proliferation were evaluated by MTT method; cell differentiation was induced by all trans-retinoic acid and the effect of organophosphates on neural differentiation was measured by microscopy technique; activity of neuropathy target esterase (NTE) was assayed by photometry; the expression levels of total and phosphorylated neurofilament heavy chain, actin were detected by Western blotting. RESULTS Mipafox and paraoxon had no effect on cell proliferation. Mipafox, but not paraoxon, significantly decreased neurite length in the retinoic acid-induced differentiation of human neuroblastoma SK-N-SH cells, compared to cells treated with vehicle. Activity of NTE was significantly inhibited by mipafox in differentiated cells, in contrast, paraoxon did not affect NTE activity. Western blot analyses revealed that the level of total neurofilament heavy chain protein (NF-H) was decreased to (23.75± 3.30) % of control cells and decreased NF-H phosphorylation was also observed following mipafox treatment. Neither mipafox nor paraoxon had significant effect on the levels of actin. CONCLUSION Mipafox inhibited the neural differentiation in human neuroblastoma SK-N-SH cell via the decrease in total NF-H and NF-H phosphorylation levels, which was associated with the inhibition of NTE activity." @default.
- W2379864786 created "2016-06-24" @default.
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- W2379864786 date "2006-01-01" @default.
- W2379864786 modified "2023-09-25" @default.
- W2379864786 title "Neurotoxic mechanism of mipafox in differentiation of human neuroblastoma SK-N-SH cells" @default.
- W2379864786 hasPublicationYear "2006" @default.
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