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- W2379867117 abstract "OBJECTIVE: To investigated the effect of reduced glutathione(GSH) on apoptosis induced by proteasome inhibition in thyroid cancer cells.METHODS: ARO,FRO,KTC2 and 8305C anaplastic thyroid cancer cells were treated with vehicle or bortezomib;Flow cytometry was used to measure apoptotic cells;Intracellular GSH,activity of glutamate cysteine ligase(GCL) and glutathione synthetase(GS) were measured using spectrophotometry;Real time PCR was performed to measure mRNA levels of GCL and GS.RESULTS:Bortezomib potently induced apoptosis of FRO and KTC2 cells compared with vehicle;Treatment with bortezomib for 24 h caused significant reduction of intracellular GSH levels in FRO and KTC2 cells(P0.01),while bortezomib treatment statistically increased intracellular glutathione levels in ARO and 8305C cells.In bortezomib treated FRO and KTC2 cells,no obvious alteration of GCL activity was observed and GCL mRNA was only slightly increased(P0.05);However,GCL activity and its mRNA levels was statistically increased 8h after bortezomib exposure in ARO and 8305C cells(P0.01).GS activity and its mRNA levels demonstrated unaffected in all the cell lines(P0.05).CONCLUSION: Proteasome inhibitor can increase GCL transcription,induce its activation,and subsequently promote intracellular GSH generation in resistant thyroid cancer cells,which leads to protect cells from apoptosis induced by proteasome inhibition." @default.
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- W2379867117 date "2012-01-01" @default.
- W2379867117 modified "2023-09-24" @default.
- W2379867117 title "Effects of reduced glutathione on apoptosis of thyroid cancer cells mediated by proteasome inhibitors" @default.
- W2379867117 hasPublicationYear "2012" @default.
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