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- W2379872266 abstract "Objective To study the effect of inhibition of Nimotuzumab(h-R3) and ionizing radiation on the growth of human esophageal carcinoma cells.Methods Human esophageal carcinoma cells were treated with h-R3 or irradiation and the both,respectively.The cell growth inhibition was assessed by MTT.Cell cycle and apoptosis were analyzed by FACS.Results The growth of Ec109 cells treated with h-R3、radiation and h-R3 combined with irradiation were all inhibited.The inhibition rate was concentration-dependent and time-dependent.The group of h-R3 combined with irradiation resulted in greater inhibiting rate(43.74%),compared with h-R3 group and radiation group(P0.05).FACS revealed that combined treatment with h-R3 and radiation could not only increase cell cycle(G2 phases)arrest but also cell apoptosis of Ec109 cells.Cells of G2(31.67%) and apoptosis rate(23.62%)for h-R3 combined with radiation group were the highest.Conclusion h-R3 significantly inhibits the proliferation of Ec109 cells in vitro.Combined treatment with h-R3 and radiation shows synergism for the inhibition of esophagus carcinoma cells growth." @default.
- W2379872266 created "2016-06-24" @default.
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- W2379872266 date "2011-01-01" @default.
- W2379872266 modified "2023-09-22" @default.
- W2379872266 title "Effects of Nimotuzumab Combined with γ-ray Radiation on Growth of the Esophageal Carcinoma Cells" @default.
- W2379872266 hasPublicationYear "2011" @default.
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