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- W2379877197 abstract "OBJECTIVE To study the expression of E-cadherin and its relationship with clinicopathological features and prognosis of the laryngeal squamous cell carcinoma, and to explore its role in the carcinogenesis and progression of the laryngeal squamous cell carcinoma. METHODS The expression level of E-cadherin in 64 tumor tissues and 30 adjacent non-tumor laryngeal tissues were determined by immunohistochemistry method. Relationship between E-cadherin staining scores and clinicopathological parameters were analyzed. Survival curves were calculated using the Kaplan-Meier method. Differences in 5-year survival rate were analyzed by the log-rank test in different E-cadherin expression groups. Multivariate Cox proportional hazards models were used to examine the relative impact of either variable on the disease prognosis. RESULTS The mean staining score of 64 carcinoma tissues was significantly lower than that of 30 non-tumor laryngeal tissues(P0.001). The expression of E-cadherin were significantly correlated with lymph node metastases(P0.001). The differences of E-cadherin expression between the different age, primary site, T stage and histological differentiation groups were not statistically significant. The 5-year survival rate in high E-cadherin expression group was significantly increased than that in low E-cadherin expression group. The result of multivariate Cox proportional hazards model confirmed that only the presence of cervical lymph node metastasis was a statistically significant independent predictor of prognosis. E-cadherin expression cannot predicate the prognosis independently. CONCLUSION The expression of E-cadherin is decreased in the laryngeal squamous cell carcinoma, it might be a potential tumor marker for occult lymph node metastasis." @default.
- W2379877197 created "2016-06-24" @default.
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- W2379877197 date "2014-01-01" @default.
- W2379877197 modified "2023-09-25" @default.
- W2379877197 title "Relationship between E-cadherin expression and lymph node metastasis, prognosis in laryngeal squamous cell carcinoma" @default.
- W2379877197 hasPublicationYear "2014" @default.
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