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- W2379886776 abstract "Objective To investigate the possible mechanism of farnesol induced death of fluconazole resistant Candida albicans. Methods Drug concentration gradient method was used to construct fluconazole resistant Candida albicans.The expression of multi-drug resistance(MDR) genes was detected by real-time quantitative PCR. Dimethyl thiazol diphenyl tetrazolium bromide(MTT) assay was used to detect the effect of farnesol on fluconazole resistant/sensitive Candida. Strain difference was compared in cell apoptosis,necrosis and reactive oxygen species(ROS) level by using flow cytometry and laser confocal microscopy. Results Fluconazole resistant Candida albicans strains were successfully constructed,and expression of MDR1 gene was significantly increased in these strains(P0.01),while there was no significant increase in expression of Candida drug resistance(CDR)2 and CDR1 gene. Compared with fluconazole sensitive Candida albicans,farnesol mediated the accumulative increase of ROS in fluconazole resistant Candida albicans,and it significantly promoted the necrosis of fluconazole resistant Candida albicans. Conclusions The MDR1 gene was overexpressed in fluconazole resistant Candida albicans; farnesol increased ROS accumulation and promoted the necrosis of fluconazole resistant Candida albicans." @default.
- W2379886776 created "2016-06-24" @default.
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- W2379886776 date "2015-01-01" @default.
- W2379886776 modified "2023-09-23" @default.
- W2379886776 title "Experimental study on farnesol induced death of fluconazole resistant Candida albicans" @default.
- W2379886776 hasPublicationYear "2015" @default.
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