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- W2379897464 abstract "Objective: To explore the neuron apoptosis induced by methamphetamine and the expression of cysteinyl aspartate specific protease,Caspase-3(Caspase-3),one protein related to apoptosis. Methods: Twenty ♂Wistar rats were selected, and randomly divided into control group(A) and experimental groups(B, C, D) ,with 5 rats in each group. Rats in group B were injected with methamphetamine (20 mg·kg~ -1 , ip,single administration),group C were ip methamphetamine 20 mg·kg~ -1 , twice a day( 8:00, 20:00) for 2 days, group D were injected with methamphetamine 20 mg·kg~ -1 ,twice a day( 8:00, 20:00) for 4 days;rats in control group were ip saline. Neuron apoptosis was measured by TUNEL, and the expression of Caspase-3 was detected by immunohistochemistry. Results: Apoptosis neurons were detected with post-treatment of methamphetamine. Different levels of expression of the protein related to apoptosis Caspase-3 were observed. Conclusion: Methamphetamine can cause neurons deficits by inducing apoptosis. Caspase-3 , the protein related to apoptosis might be involved in the progress of apoptosis." @default.
- W2379897464 created "2016-06-24" @default.
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- W2379897464 date "2006-01-01" @default.
- W2379897464 modified "2023-09-25" @default.
- W2379897464 title "METHAMPHETAMINE-INDUCED NEURON APOPTOSIS AND CASPASE-3 EXPRESSION" @default.
- W2379897464 hasPublicationYear "2006" @default.
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