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- W2379899926 abstract "Objective To investigate the implications of expressive activity of tumor suppressing gene PTEN in the tissues of laryngeal carcinoma(LC). Methods Sixty-five cases with LC and 30 cases with nodules or polyp of vocal cord were included in this study,taken as observing group or controlling one respectively.The techniques utilized here were immunohistochemical SABC procedures to detect the expression of PTEN in paraffin-embedded tissue samples of these cases.Then,an analysis was made to explore the association of PTEN expression with the features of clinical pathology among them. Results The positive expressing rate of PTEN was significantly lower in LC tissues(52.3%) than that in begin laryngeal lesions(96.7%),P0.05.Furthermore,its expressing rate was significantly higher among the cases with the primary foci of LC at stages of T1(71.4%) or T2(63.3%) than those at stages of T3(25.0%) or T4(22.2%) respectively,P0.05.This rate was also significantly higher among the cases with glottic type of LC(65.8%) than those with supra-or hypo-glottic type of LC(34.8% and 25.0% respectively),P0.05.The similar tendencies of implications were true for the associations of PTEN expression with the level of differentiation and the metastatic condition of neck lymph nodes as well. Conclusions The level of PTEN expression should be involved in the process of laryngeal tumorogenesis and LC developing and is associated with the clinicopathological features of this tumor." @default.
- W2379899926 created "2016-06-24" @default.
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- W2379899926 date "2005-01-01" @default.
- W2379899926 modified "2023-09-25" @default.
- W2379899926 title "The implications of PTEN expression in laryngeal carcinoma" @default.
- W2379899926 hasPublicationYear "2005" @default.
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