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- W2379920508 abstract "Objective To investigate the effect of silencing LKB1 by small interfering RNA(siRNA)on the expression of the correlation factor of Hedgehog signaling pathways in human breast cancer MDA-MB-231 cells and the growth of xenografted breast carcinoma in nude mice.Methods Plasmids of siRNA for LKB1 gene were constructed.RNA interference technique was used to silence LKB1 gene in breast carcinoma cells,xenografted tumor model was established in nude mice by subcutaneous inoculation of MDA-MB-231 cells.The tumor volume and survival time of nude mice were recorded.The expression of LKB1,Shh,Sufu,Gli 1,Ptch,Smo and Hip was measured by Western blotting.Results The tumor size was significantly increased in LKB1-siRNA treated group(P0.01).Western blotting analysis showed that the expression of LKB1 in xenografted tumor was markedly decreased and the correlation factor of Hedgehog signaling pathways was significantly elevated compared with control groups.But the inhibiting factor of Hedgehog signaling pathways was markedly decreased.Conclusion LKB1-siRNA markedly silenced the expression of LKB1 gene,up-regulated the expression of the correlation factor of Hedgehog signaling pathways,advanced the growth of xenografted tumor.LKB1 and Hedgehog signaling pathways were negatively correlated in breast cancer cells." @default.
- W2379920508 created "2016-06-24" @default.
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- W2379920508 date "2011-01-01" @default.
- W2379920508 modified "2023-09-24" @default.
- W2379920508 title "Silencing LKB1 by siRNA activated Hedgehog signaling pathway and the growth of xenografted breast carcinoma in nude mice" @default.
- W2379920508 hasPublicationYear "2011" @default.
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