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- W2379928035 abstract "Objective: Explore the change of bone mineral density and bone metabolism in male patients with ankylosing spondylitis by short-term and low-dose glucocorticoid. Methods: Randomly divide 46 patients into non-GC treatment group(22) and low-dose GC treatment group(24). Non-GC treatment group receive DMARD and Ca, Low-dose GC treatment group receive low dose glucocorticoid as well as DMARD and Ca. The Serum levels of osteoprotegerin(OPG), macrophage-colony stimulating factors(M-CSF), erythrocyte sedimentation rate(ESR), c-reactive protein(CRP), bath AS disease activity index(BASDAI) and Bone mineral density(BMD) were measured at the baseline and 6 months after therapy. Results: Six months after treatment, the level of OPG increased signifi cantly(P0.05) and the level of ESR, CRP, BASDAI decreased signifi cantly(P0.05) in both groups respectively, compared with that at the baseline; the level of M-CSF of two treatment groups decreased, in which the low-dose GC treatment group did more signifi cantly(P0.05). Six months after treatment, there was no signifi cant difference in the levels of OPG, M-CSF, and BMD(P0.05) between the two groups. There was signifi cant difference in the levels of ESR, CRP, BASDAI between the two groups(P0.05).Conclusion: Short-term treatment of low-dose GC affect bone metabolisms and infl amed index, while with no signifi cant infl uence on BMD in AS patients. It is safe and benefi t for AS patients." @default.
- W2379928035 created "2016-06-24" @default.
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- W2379928035 date "2014-01-01" @default.
- W2379928035 modified "2023-09-26" @default.
- W2379928035 title "Affection of short-term and low-dose glucocorticoid on bone mineral density and bone metabolism in the treatment of male patients with ankylosing spondylitis" @default.
- W2379928035 hasPublicationYear "2014" @default.
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