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- W2379931425 abstract "Objective To evaluate the clinical value of the midnight serum cortisol in the diagnosis of Cushing's syndrome,and to explore the best cut-off value.Methods The clinical data of 285 patients surgically conformed as Cushing's syndrome and 146 patients with pseudo-Cushing's states in Chinese PLA General Hospital in 1991-2011 were retrospectively analyzed.The levels of serum cortisol were determined at 8:00,16:00,00:00 in all patients.ROC curve was used to evaluate the efficacy of the midnight serum cortisol in the diagnosis of Cushing's syndrome.The best cut-off value and its corresponding sensitivity and specificity were calculated.Results The AUCs of serum cortisol at 8:00,16:00,0:00 in diagnosing Cushing's syndrome were 0.904,0.930 and 0.984,respectively,and their corresponding diagnostic accuracies were 84.5%,91.5% and 94.5%.The best cut-off value of serum cortisol at 8:00 was 502 nmol/L with sensitivity of 82.6% and specificity of 88.2%,505.6 nmol/L at 16:00 with sensitivity of 88.7% and specificity of 97.7%,249nmol/L at 00:00 with sensitivity of 96.2% and specificity of 91.6%.Conclusion Midnight serum cortisol is better than those at the other time points in the diagnosis of Cushing's syndrome.Midnight serum cortisol level at 249 nmol/L has higher sensitivity and specificity." @default.
- W2379931425 created "2016-06-24" @default.
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- W2379931425 date "2012-01-01" @default.
- W2379931425 modified "2023-09-25" @default.
- W2379931425 title "Value of midnight serum cortisol in the diagnosis of Cushing's syndrome" @default.
- W2379931425 hasPublicationYear "2012" @default.
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