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- W2379934217 abstract "Objective To investigate the correlation between the TSLC1 protein expression and the clinicopathological parameters in breast cancer,and to explore its roles in the formation and development of breast cancer. Methods The expression of TSLC1 protein in 50 breast cancer samples and 50 pericancerous normal breast tissues was examined by immunohistochemistry SP method. The significance of TSLC1 in the development of breast cancer was analyzed by investigating the relationship between the expression levels of TSLC1 protein and the clinicopathological parameters of breast cancer patients. Results The positive expression rate of TSLC1 in breast carcinoma (40%,20/50) was significantly lower than that in nearby non-tumorous tissues (92%,46/50; P0.01). The positive expression rate of TSLC1 in non-invasive and invasive breast carcinomas was 71.4% (5/7) and 34.9% (15/43) respectively,which showed a decreasing tendency of positive rate with the advancing invasion,though without significant difference (P0.05). There was also significant difference in TSLC1 protein expression between breast carcinomas with lymph node metastasis (50%,11/22) and without lymph node metastasis (89%,25/28; P0.05). No significant correlation was found between TSLC1 expression level and tumor size or patient's age or tumor stage. Conclusions TSLC1 protein may exert inhibitory effect on the development of breast cancer,and its expression may be related to the infiltration and metastasis of breast cancer." @default.
- W2379934217 created "2016-06-24" @default.
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- W2379934217 date "2009-01-01" @default.
- W2379934217 modified "2023-09-24" @default.
- W2379934217 title "Expression of TSLC1 Protein in Breast Cancer and Its Clinical Significance" @default.
- W2379934217 hasPublicationYear "2009" @default.
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