Matches in SemOpenAlex for { <https://semopenalex.org/work/W2379941275> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2379941275 endingPage "509" @default.
- W2379941275 startingPage "505" @default.
- W2379941275 abstract "1. Cardiopulmonary bypass is associated with an increase in nitric oxide concentrations, and plasma levels of tumour necrosis factor and interleukin-1. Aprotinin, a serine protease inhibitor, commonly used during cardiopulmonary bypass to reduce blood loss, has been demonstrated to exhibit significant anti-inflammatory effects during and after cardiopulmonary bypass. 2. Airway nitric oxide was measured during cardiopulmonary bypass in 10 controls (Group 1), 10 subjects receiving half-dose aprotinin (Group 2) and 10 patients receiving full-dose aprotinin (Group 3). In vitro, a murine bronchial epithelial cell line (LA-4) was cultured with cytomix (a combination of tumour necrosis factor, interleukin-1, and (γ-interferon) with and without aprotinin in increasing concentrations. Nitrite concentrations, the stable and measureable end-product of nitric oxide oxidative metabolism, were measured in the culture supernatant by chemiluminescence. 3. Airway nitric oxide concentrations were increased after 50 min cardiopulmonary bypass compared with that measured at 5 min in controls (53 ± 5 versus 29 ± 3 ppb, P < 0.05) but not in the aprotinin-treated groups (25 ± 4 versus 14 ± 5, Group 2; 21 ± 6 versus 15 ± 3 ppb, Group 3). 4. In a dose-dependent manner, nitrite levels (means ± S.E.M.) were significantly reduced by aprotinin at 500 and 1000 units/ml when compared with cells cultured in the presence of cytomix alone (P < 0.05). 5. These data demonstrate that aprotinin, in a dose-responsive manner, reduces nitric oxide production in vivo and reduces cytokine-induced nitrite production by murine bronchial epithelial cells in vitro. Since increased airway nitric oxide is found in inflammatory lung diseases, like asthma, and anti-inflammatory therapy reduces the concentration of airway nitric oxide, these data support the concept that aprotinin is anti-inflammatory during cardiopulmonary bypass." @default.
- W2379941275 created "2016-06-24" @default.
- W2379941275 creator A5011584553 @default.
- W2379941275 creator A5059655752 @default.
- W2379941275 creator A5072703847 @default.
- W2379941275 date "1998-05-01" @default.
- W2379941275 modified "2023-10-17" @default.
- W2379941275 title "Aprotinin Reduces Nitric Oxide Production <i>in Vitro</i> and <i>in Vivo</i> in a Dose-Dependent Manner" @default.
- W2379941275 cites W136754475 @default.
- W2379941275 cites W1760011089 @default.
- W2379941275 cites W1902360293 @default.
- W2379941275 cites W1947666932 @default.
- W2379941275 cites W1989697230 @default.
- W2379941275 cites W2011347602 @default.
- W2379941275 cites W2042748276 @default.
- W2379941275 cites W2043474235 @default.
- W2379941275 cites W2086529488 @default.
- W2379941275 cites W2091045350 @default.
- W2379941275 cites W2100582668 @default.
- W2379941275 cites W2313326603 @default.
- W2379941275 cites W2345586391 @default.
- W2379941275 cites W35243478 @default.
- W2379941275 doi "https://doi.org/10.1042/cs0940505" @default.
- W2379941275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9682673" @default.
- W2379941275 hasPublicationYear "1998" @default.
- W2379941275 type Work @default.
- W2379941275 sameAs 2379941275 @default.
- W2379941275 citedByCount "27" @default.
- W2379941275 countsByYear W23799412752014 @default.
- W2379941275 countsByYear W23799412752015 @default.
- W2379941275 countsByYear W23799412752023 @default.
- W2379941275 crossrefType "journal-article" @default.
- W2379941275 hasAuthorship W2379941275A5011584553 @default.
- W2379941275 hasAuthorship W2379941275A5059655752 @default.
- W2379941275 hasAuthorship W2379941275A5072703847 @default.
- W2379941275 hasConcept C126322002 @default.
- W2379941275 hasConcept C150903083 @default.
- W2379941275 hasConcept C178790620 @default.
- W2379941275 hasConcept C185592680 @default.
- W2379941275 hasConcept C207001950 @default.
- W2379941275 hasConcept C2776179834 @default.
- W2379941275 hasConcept C2776384668 @default.
- W2379941275 hasConcept C2777622882 @default.
- W2379941275 hasConcept C2778881276 @default.
- W2379941275 hasConcept C2780799893 @default.
- W2379941275 hasConcept C42219234 @default.
- W2379941275 hasConcept C519581460 @default.
- W2379941275 hasConcept C71924100 @default.
- W2379941275 hasConcept C86803240 @default.
- W2379941275 hasConcept C98274493 @default.
- W2379941275 hasConceptScore W2379941275C126322002 @default.
- W2379941275 hasConceptScore W2379941275C150903083 @default.
- W2379941275 hasConceptScore W2379941275C178790620 @default.
- W2379941275 hasConceptScore W2379941275C185592680 @default.
- W2379941275 hasConceptScore W2379941275C207001950 @default.
- W2379941275 hasConceptScore W2379941275C2776179834 @default.
- W2379941275 hasConceptScore W2379941275C2776384668 @default.
- W2379941275 hasConceptScore W2379941275C2777622882 @default.
- W2379941275 hasConceptScore W2379941275C2778881276 @default.
- W2379941275 hasConceptScore W2379941275C2780799893 @default.
- W2379941275 hasConceptScore W2379941275C42219234 @default.
- W2379941275 hasConceptScore W2379941275C519581460 @default.
- W2379941275 hasConceptScore W2379941275C71924100 @default.
- W2379941275 hasConceptScore W2379941275C86803240 @default.
- W2379941275 hasConceptScore W2379941275C98274493 @default.
- W2379941275 hasIssue "5" @default.
- W2379941275 hasLocation W23799412751 @default.
- W2379941275 hasLocation W23799412752 @default.
- W2379941275 hasOpenAccess W2379941275 @default.
- W2379941275 hasPrimaryLocation W23799412751 @default.
- W2379941275 hasRelatedWork W1969002119 @default.
- W2379941275 hasRelatedWork W1972194921 @default.
- W2379941275 hasRelatedWork W1985900017 @default.
- W2379941275 hasRelatedWork W1993871158 @default.
- W2379941275 hasRelatedWork W2055860776 @default.
- W2379941275 hasRelatedWork W2123248959 @default.
- W2379941275 hasRelatedWork W2234525213 @default.
- W2379941275 hasRelatedWork W2379941275 @default.
- W2379941275 hasRelatedWork W4232735058 @default.
- W2379941275 hasRelatedWork W2108732647 @default.
- W2379941275 hasVolume "94" @default.
- W2379941275 isParatext "false" @default.
- W2379941275 isRetracted "false" @default.
- W2379941275 magId "2379941275" @default.
- W2379941275 workType "article" @default.