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- W2379942568 abstract "Objective To observe the therapeutic effect of Chinese recombinant human growth hormone(rhGH) on the growth of children with idiopathic short stature(ISS).Methods Ninety-eight children with short stature involved in this study.According to the etiological factors,the children were assigned into 2 groups: ISS group(n=30) and growth hormone deficiency(GHD) group(n=68).Both groups were received subcutaneous administration of home-made rhGH for 0.15 IU/(kg·d) and 0.1 IU/(kg·d)respectively before sleeping within 6 months.The body height,body mass and bone age were measured and the growth rate was calculated before 3 and 6 months after treatment.Results The growth rate of children in two groups 3 and 6 months after treatment were significantly superior to those before treatment [ISS group:(7.3±2.9),(7.5±2.7),(3.5±2.1)cm/year,P0.01;GHD group:(13.2±3.5),(13.5±3.6),(4.0±2.9)cm/year,P0.01].Six months after treatment,body height increased in 27 of 30 children in ISS groups,and in all the 68 children in GHD group.The growth rate of children in GHD group was concurrently higher than those in ISS group 3 and 6 months after treatment.Conclusions Home-made rhGH is a safe and effective reagent for treatment of ISS,but the inhomogeneity of treatment effect does exist and therapeutic effect in ISS children is inferior to that in GHD children." @default.
- W2379942568 created "2016-06-24" @default.
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- W2379942568 date "2007-01-01" @default.
- W2379942568 modified "2023-09-24" @default.
- W2379942568 title "Therapeutic Effect of Chinese Domestic Recombinant Human Growth Hormone in Children with Idiopathic Short Stature" @default.
- W2379942568 hasPublicationYear "2007" @default.
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