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- W2379951544 abstract "Objective:To study the expression and significance of relevant apoptosis genes, Fas and FasL, on peripheral blood mononuclear cells (PBMC) of patients with nasopharyngeal carcinoma (NPC) before and after the induction chemotherapy, and to investigate their function and clinical value in occurrence, development and treatment of NPC.Methods:Expression of Fas and FasL on PBMC of 38 patients with NPC before and after the induction chemotherapy and 15 normal healthy controls were tested with flow cytometry, and analysed with clinical information.Results:①The expression of Fas and FasL on PBMC in NPC patients was much higher than that in normal healthy controls (P0.05). The expression of Fas and FasL on PBMC in NPC patients of stage Ⅲ+Ⅳ were much higher than that in stage Ⅱ (P0.05).②The expression of Fas on PBMC in NPC patients of Stage T_(3+4) was much higher than that in stage T_(1+2)(P0.05), but there was no obvious change in expression of FasL (P0.05).③ The expression of Fas on PBMC in NPC patients of stage N_(1) was much higher than that in stage N_(0)(P0.05), there was no obvious change in expression of FasL (P0.05). The expression of Fas on PBMC in NPC patients of stage N_(2+3) was much higher than that in N_(1) (P0.05), but there was no obvious change in expression of FasL (P0.05).④For NPC patients received induction chemotherapy, the expression of Fas increased obviously compared with it before the chemotherapy (P0.05), there was no obvious change in expression of FasL (P0.05).Conclusion:The expression of Fas and FasL on PBMC shows certain significance for occurrence, multiplication and local metastasis of NPC. It can also help diagnose of NPC and judge its stage." @default.
- W2379951544 created "2016-06-24" @default.
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- W2379951544 date "2005-01-01" @default.
- W2379951544 modified "2023-09-23" @default.
- W2379951544 title "The Expression and Significance of Fas and FasL on Peripheral Blood Mononuclear Cell of Patients with Nasopharyngeal Carcinoma" @default.
- W2379951544 hasPublicationYear "2005" @default.
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