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- W2379968572 abstract "Objective To explore the effect of brain derived neurotrophic factor(BDNF) on the birth weight and the brain weight of newborn rats with intrauterine growth retardation(IUGR).Methods Female and male Sprague-Dawley rats were mated together and the vaginal plug formation after mating was for pregnancy diagnosis.The day when the plug was observed was considered day 1 of gestation.Then,the pregnant rats were divided into IUGR group and sham surgery group.On day 17 of gestation,the uterine arteries of pregnant rats in IUGR group were clamped for 30 min by blood vessel forceps after abdominal cavity with clamping blood uessels was opened.The pegnant rats in sham surgery group only had abdominal cavity opened without clamping blood vessels.Then the pegnant rats in IUGR group received 9 g/L saline(IUGR group) or BDNF 1 μg injected in the rat through caudal veins for 5 days after surgery(BDNF intervention group).After vaginal birth,the weight of newborn rats and their brain weigh were measured and analyzed.Results Compared with the sham surgery group,the birth weight and brain weight of IUGR group group rats decreased by 24.9% and 17.3%,respectively,the results were significant(Pa0.000 1).And the weight of newborn rats and their brain of BDNF intervention group was significantly higher than those in IUGR group(Pa0.05).Compared with the IUGR group,the birth weight and the brain weight of BDNF IUGR group rats increased 11.9% and 10.7% for IUGR.Conclusions BDNF injection by rat caudal veins can increase the birth weight and the brain weight of newborn rats suffered from intrauterine growth retardation,which provides the possibility of using BDNF for drug therapy intervention of IUGR in the future." @default.
- W2379968572 created "2016-06-24" @default.
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- W2379968572 date "2008-01-01" @default.
- W2379968572 modified "2023-09-24" @default.
- W2379968572 title "Effect of Brain Derived Neurotrophic Factor on the Birth Weight and the Brain Weight of Newborn Rats with Intrauterine Growth Retardation" @default.
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