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- W2379969000 abstract "Objective:Based on available evidence,we analyzed the efficacy and safety of dabigatran,apixaban and rivaroxaban versus low-molecular-weight heparins(LMWHs) as venous thromboembolism prophylaxis in major orthopedic surgery.Methods:We systematically searched the randomized controlled trials reported in Pub Med and Embase and key articles listed in the reference which evaluated apixaban,dabigatran,or rivaroxaban versus LMWHs in patients receiving major orthopedic surgeries.One of the following outcome was to be evaluated:total venous thromboembolism(VTE),deep vein thrombosis(DVT),pulmonary embolism(PE),death and major bleeding.Three reviewers assessed each article to determine methodological quality and extracted data independently.Results:The assessed outcomes include total VTE,DVT,PE,death and major bleeding events.3 authors assessed the methodology quality of each article and extracted data from the literature dependently.For the prevention of total VTE,rivaroxaban and apixaban were superior to dabigatran with RR of 0.37(95% CI 0.23-0.60) 0.58(95% CI 0.35-0.96) respectively.There was no significant difference between rivaroxaban and apixaban with RR of 0.64(95% CI 0.33-1.25).Rivaroxaban increased hemorrhage with an RR of 1.57(95% CI 1.20-2.07) compared to apixaban,and also increases the overall hemorrhage risk with an RR of 1.25(95% CI 0.93-1.70) compared to dabigatran.There was no significant difference between apixaban and dabigatran with an RR of 0.78(95% CI 0.58-1.07).Conclusion:Compared to dabigatran,rivaroxaban and apixaban are more efficacious with similar hemorrhage risk in prevention of total VTE in patients receiving major orthopedic surgery.Compared to apixaban,rivaroxaban has similar efficacy in prevention of total VTE but it can increase the hemorrhage risk." @default.
- W2379969000 created "2016-06-24" @default.
- W2379969000 creator A5004874779 @default.
- W2379969000 date "2015-01-01" @default.
- W2379969000 modified "2023-09-23" @default.
- W2379969000 title "Prevention of venous thromboembolism in major orthopedic surgery:a systematic review and adjusted indirect comparison of oral anticoagulants" @default.
- W2379969000 hasPublicationYear "2015" @default.
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