Matches in SemOpenAlex for { <https://semopenalex.org/work/W2379972408> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2379972408 abstract "Objective To assess the relationship between the polymorphisms of DNA repair gene XRCC1 Pro206Pr and Gln632Gln and susceptibility of lung cancer among non-smoking Chinese women.Methods A hospital-based case-control study consisting of 55 newly diagnosed and previously untreated subjects with lung cancer and 74 cancer-free control subjects matched on age(±3 years),gender and ethnicity was conducted.All subjects were unrelated ethnic Han Chinese and lifetime non-smoking women from northeastern China.Genotypes were determined by PCR-RFLP method.Results Variant G-allele of XRCC1 Pro206Pro was significantly over-represented in lung cancer patients(G versus A,OR=3.69,95%CI=1.46-9.34,P=0.004).Carriers of the variant G-allele of Pro206Pro were at significantly increased risk of lung cancer(AG+GG versus AA,OR=3.93,95%CI=1.47-10.52,P=0.004).No significant effect was observed for polymorphism of XRCC1 Gln632Gln.Overall haplotype distribution was significant different between cases and controls(P=0.005).Hapolotype(Pro206Pro〔G〕-Gln632Gln〔A〕)defined by combination of variant alleles in the two polymorphisms was a high-risk haplotype of lung cancer susceptibility(OR=4.04,95%CI=1.36-11.96,P=0.007).The two polymorphisms were in strong linkage disequilibrium(D'=0.702).Conclusion The present results are consistent with our previous findings that variant G-allele of DNA repair gene XRCC1 Pro206Pro or a haplotype encompassing it's alleles may be an important susceptibility factor in the process of lung cancer developonent in non-smoking Chinese women.Larger sample studies will be required further to validate these findings." @default.
- W2379972408 created "2016-06-24" @default.
- W2379972408 creator A5052650725 @default.
- W2379972408 date "2009-01-01" @default.
- W2379972408 modified "2023-09-27" @default.
- W2379972408 title "Polymorphisms of DNA repair gene XRCC1 Pro206Pro and Gln632Gln and genetic susceptibility of lung cancer among non-smoking Chinese women" @default.
- W2379972408 hasPublicationYear "2009" @default.
- W2379972408 type Work @default.
- W2379972408 sameAs 2379972408 @default.
- W2379972408 citedByCount "0" @default.
- W2379972408 crossrefType "journal-article" @default.
- W2379972408 hasAuthorship W2379972408A5052650725 @default.
- W2379972408 hasConcept C104317684 @default.
- W2379972408 hasConcept C126322002 @default.
- W2379972408 hasConcept C135763542 @default.
- W2379972408 hasConcept C143998085 @default.
- W2379972408 hasConcept C146304588 @default.
- W2379972408 hasConcept C153209595 @default.
- W2379972408 hasConcept C180754005 @default.
- W2379972408 hasConcept C197754878 @default.
- W2379972408 hasConcept C2776256026 @default.
- W2379972408 hasConcept C2776999993 @default.
- W2379972408 hasConcept C2779372377 @default.
- W2379972408 hasConcept C35605836 @default.
- W2379972408 hasConcept C54355233 @default.
- W2379972408 hasConcept C67636389 @default.
- W2379972408 hasConcept C71924100 @default.
- W2379972408 hasConcept C86803240 @default.
- W2379972408 hasConcept C90924648 @default.
- W2379972408 hasConceptScore W2379972408C104317684 @default.
- W2379972408 hasConceptScore W2379972408C126322002 @default.
- W2379972408 hasConceptScore W2379972408C135763542 @default.
- W2379972408 hasConceptScore W2379972408C143998085 @default.
- W2379972408 hasConceptScore W2379972408C146304588 @default.
- W2379972408 hasConceptScore W2379972408C153209595 @default.
- W2379972408 hasConceptScore W2379972408C180754005 @default.
- W2379972408 hasConceptScore W2379972408C197754878 @default.
- W2379972408 hasConceptScore W2379972408C2776256026 @default.
- W2379972408 hasConceptScore W2379972408C2776999993 @default.
- W2379972408 hasConceptScore W2379972408C2779372377 @default.
- W2379972408 hasConceptScore W2379972408C35605836 @default.
- W2379972408 hasConceptScore W2379972408C54355233 @default.
- W2379972408 hasConceptScore W2379972408C67636389 @default.
- W2379972408 hasConceptScore W2379972408C71924100 @default.
- W2379972408 hasConceptScore W2379972408C86803240 @default.
- W2379972408 hasConceptScore W2379972408C90924648 @default.
- W2379972408 hasLocation W23799724081 @default.
- W2379972408 hasOpenAccess W2379972408 @default.
- W2379972408 hasPrimaryLocation W23799724081 @default.
- W2379972408 hasRelatedWork W1503916802 @default.
- W2379972408 hasRelatedWork W1924712043 @default.
- W2379972408 hasRelatedWork W1965576720 @default.
- W2379972408 hasRelatedWork W2014275838 @default.
- W2379972408 hasRelatedWork W2039143344 @default.
- W2379972408 hasRelatedWork W2050243371 @default.
- W2379972408 hasRelatedWork W2077459815 @default.
- W2379972408 hasRelatedWork W2095234954 @default.
- W2379972408 hasRelatedWork W2155126651 @default.
- W2379972408 hasRelatedWork W2349981731 @default.
- W2379972408 hasRelatedWork W2363070047 @default.
- W2379972408 hasRelatedWork W2371396819 @default.
- W2379972408 hasRelatedWork W2395839129 @default.
- W2379972408 hasRelatedWork W2411189890 @default.
- W2379972408 hasRelatedWork W2471270972 @default.
- W2379972408 hasRelatedWork W2739977953 @default.
- W2379972408 hasRelatedWork W2955348964 @default.
- W2379972408 hasRelatedWork W3028291478 @default.
- W2379972408 hasRelatedWork W3035951804 @default.
- W2379972408 hasRelatedWork W3044128010 @default.
- W2379972408 isParatext "false" @default.
- W2379972408 isRetracted "false" @default.
- W2379972408 magId "2379972408" @default.
- W2379972408 workType "article" @default.