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- W2379975136 abstract "The aim of this project was to find some kinds of Chinese medicines as effective agents for reversal of cancer multidrug resistance.Based on the present authors'previous researches,thirty-two kinds of Chinese medicines as research materials were selected and examined.Using cell growth inhibition assay,the authors found that three of them,Ams-11,Fw-13 and Tul-17,in the doses free from cytotoxicity could enhance the senstivity of multidrug resistant cells to anticancer drugs in a dose-dependent way.Through mechanistic studies,the authors demonstrated that Tul-17 could increase the accumulation of MDR drugs,and attenuate the expression level of P-glycoprotein(Pgp).Animal test with Fw-13 also proved the MDR reversal effect of this medicine.Taken together,the results indicate that these three Chinese medicines might be potential effective MDR reversal agents." @default.
- W2379975136 created "2016-06-24" @default.
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- W2379975136 date "2006-01-01" @default.
- W2379975136 modified "2023-09-24" @default.
- W2379975136 title "Reversal of P-glycoprotein Mediated Multidrug Resistance by Traditional Chinese Medicines" @default.
- W2379975136 hasPublicationYear "2006" @default.
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