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- W2379981431 abstract "Objective To examine the roitogenic effect of substance P(SP)on gastric cancer cells.Methods MKN45 cells were cultured in RPMI 1640.The G protein-coupled receptor(NK-1)ex- pressed by MKN45 cells was detected by immunohistochemistry staining using the avidin-biotin-peroxidase complex method.5P at different concentrations was added into the RPMI 1640.~3H-TdR incorporation rate was used as an index of MKN45 cell proliferation.G protein-coupled receptor antagonist(ASN-1377642) was used with concentration of 500 mool/L to investigate the mitogenesis of MKN45 stimulated by SP.Re- sults Gastric cancer cell MKN45 expressed NK-1.SP at the concentration of 10-100 nmol/L increased DNA synthesis rate of MKN45 cells significantly.The effects of SP on MKN45 cell proliferation were dose- dependent,and were not enhanced when the concentration was over 100 nmol/L.ASN-1377642 inhibited SP-promoting mitogenic effects in vitro.Conclusion Gastric cancer cells expressed NK-1,the receptor of SP.SP could promote the prolieration of gastric cancer cells by binding with NK-1." @default.
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- W2379981431 date "2007-01-01" @default.
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- W2379981431 title "The mitogenic effect of substance P on gastric cancer cells" @default.
- W2379981431 hasPublicationYear "2007" @default.
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