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- W2380014458 abstract "Objective To investigate the expressons of vascular endothelial growth factor(VEGF) in childhood proliferated hemangiomas ,its adjacent tissue and serum for further understanding the biochemical characteristics of hemangiomas.Methods The blood sample and proliferated fresh tissues from hemangiomas and its adjacent tissues were collected. The VEGF concentration was measured by ELISA test. The cDNA of VEGF composed first and the quantity of VEGF mRNA from the tumor and its adjacent tissues were detected and measured in the fluroscent PCR machine by reverse transcription-polymerase chain reaction(RT-PCR). Results VEGF in patient's serum was significantly higher than that of control group. The electrophoresis showed strong positiveness,the expressions of VEGF were 100 %(9/9) and 88.9 %(8/9) in hemangiomas and its adjacent tissues respectively. The high expression of VEGF was detected and quantified by the fluroscent PCR machine. The amount of VEGF mRNA in hemangiomas and its adjacent tissues were much higher than those of control group(P0.01). However there was no difference between the tumor and its adjacent tissues.Conclusion VEGF may stimulate vascular endothelial cells to proliferate and differentiate toward the hemangiomas. The measurement of VEGF in the peripheral blood might be a useful method for analying hemangiomas classification and recurrence evaluation." @default.
- W2380014458 created "2016-06-24" @default.
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- W2380014458 date "2004-01-01" @default.
- W2380014458 modified "2023-09-26" @default.
- W2380014458 title "Expressions of vascular endothelial growth factor in both proliferated hemangiomas and serum" @default.
- W2380014458 hasPublicationYear "2004" @default.
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