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- W2380015280 abstract "Objective: To investigate the expression profile of lipocalin-prostaglandin D synthase(LPGDS) and prostaglandin D receptor(DP) in mouse uterus during early pregnancy to observe their roles in the implantation and maintenance of pregnancy.Methods: Semi-quantitative RT-PCR was used to detect the expression of LPGDS and DP in mouse(uterus) from day 1(D 1) to day 8(D 8) of pregnancy,and their expressions in the implantation site and(interimplantation) site on D5 were compared.Results: The LPGDS mRNA levels from D 2 to D 4 were significantly higher than those on D 1,D 5,D 6,D 7 and D 8(P0.01);the DP mRNA levels from D 5-D 8 were significantly higher than those from D 1-D 4(P0.01).No significant difference was found in the LPGDS mRNA levels between the implantation site and inter-implantation site on D 5 of pregnancy,but DP mRNA levels in the inter-implantation site were higher than those in the implantation site.Conclusions: The high expression of LPGDS in pre-implantation uterus suggests that LPGDS may be involved in the preparation of uterus for embryo implantation.Higher expression of DP after embryo(implantation) may play an important role in the maintenance of pregnancy." @default.
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- W2380015280 date "2006-01-01" @default.
- W2380015280 modified "2023-09-25" @default.
- W2380015280 title "Expression of lipocalin-prostaglandin D synthase and prostaglandin D receptor in mouse uterus during early pregnancy" @default.
- W2380015280 hasPublicationYear "2006" @default.
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