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- W2380026063 abstract "Objective To determine the drug-susceptibility of Malassezia furfur by using modified ATB Fungus 3 method and evaluate the minimum inhibitory concentration(MIC) of clinical isolates of Malassezia furfur to antifungal agents.Methods Tween-40 and Tween-60 were added into ATB F2 semisolid culture media with final concentration of 0.5%.The MICs of 5 antifungal agents against 47 strains of Malassezia furfur were determined by ATB Fungus 3 method.Results The MIC50 of fluconazole,5-flucytosine,voriconazole,amphotericin B and itraconazole against 47 Malassezia furfur strains were more than 128,more than 16,8.0,4.0 and 1.0 μg/mL respectively,and the ranges of MIC were less than or equal to1.0 to more than 128 μg/mL,more than 16 μg/mL,less than or equal to 0.06 to more than 8.0 μg/mL,less than or equal to 0.5 to 16 μg/mL,less than or equal to 0.125 to 4.0 μg/mL.The results showed that the MIC values of 5 antifungal agents against clinical isolates of Malassezia furfur from respiratory tract were higher than those of typical strain ATCC 14521 and the Malassezia furfur strains isolated from normal human skin.Conclusion The improved ATB Fungus 3 method with good reproducible results should be easily available for the determination of drug-susceptibility of Malassezia furfur.The high MICs of antifungal agents against clinical isolates of Malassezia furfur may be due to increased application of antifungal agents." @default.
- W2380026063 created "2016-06-24" @default.
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- W2380026063 date "2012-01-01" @default.
- W2380026063 modified "2023-09-23" @default.
- W2380026063 title "Antifungal susceptibility of Malassezia furfur in vitro tested by using modified ATB Fungus 3 method" @default.
- W2380026063 hasPublicationYear "2012" @default.
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