Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380040937> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2380040937 abstract "Objective To establish a model of terbinafine-resistance Candida albicans induced by terbinafine in vitro and to investigate the stability of resistance and the biological phenotype variation between the terbinafine-resistant Candida albicans and its matched susceptible strain.Methods Terbinafine-sensitive Candida albicans strain ATCC90028 was experimentally serially subcultured in YPD medium containing increasing concentrations of terbinafine to generate Candida albicans strain ATCC90028-R that is resistant to terbinafine.The susceptibilities of this parental strain and its resistant filial generation to terbinafine were measured respectively.The resistant filial generation that induced by 1024μg/ml of terbinafine was subcultured in drug-free medium for 10 times consecutively and then their susceptibilities to terbinafine were measured respectively for investigating the stability of resistance.Phenotype variation between the terbinafine-resistant Candida albicans and its matched susceptible strain were compared by naked eye,light microscope and electron microscope respectively.Results Terbinafine-susceptible Candida albicans strain ATCC90028(MIC=8μg/ml) was successfully induced by terbinafine to generate terbinafine-resistant Candida albicans strain ATCC90028-R(MIC≥512μg/ml),and the induced terbinafine-resistant strain maintained drug resistance when it was subcultured in drug-free medium for 10 passages consecutively.But its growth and multiplication was torpid,and its cell morphous was irregular.Conclusion The stable terbinafine-resistant Candida albicans strain ATCC90028-R was successfully induced and proved by in vitro tests." @default.
- W2380040937 created "2016-06-24" @default.
- W2380040937 creator A5057687171 @default.
- W2380040937 date "2007-01-01" @default.
- W2380040937 modified "2023-09-24" @default.
- W2380040937 title "In vitro study on stepwise induction of Candida albicans resistance and reversion to terbinafine" @default.
- W2380040937 hasPublicationYear "2007" @default.
- W2380040937 type Work @default.
- W2380040937 sameAs 2380040937 @default.
- W2380040937 citedByCount "0" @default.
- W2380040937 crossrefType "journal-article" @default.
- W2380040937 hasAuthorship W2380040937A5057687171 @default.
- W2380040937 hasConcept C105702510 @default.
- W2380040937 hasConcept C114851261 @default.
- W2380040937 hasConcept C202751555 @default.
- W2380040937 hasConcept C2777071850 @default.
- W2380040937 hasConcept C2778022156 @default.
- W2380040937 hasConcept C2778236110 @default.
- W2380040937 hasConcept C2779548794 @default.
- W2380040937 hasConcept C2780917455 @default.
- W2380040937 hasConcept C55493867 @default.
- W2380040937 hasConcept C86803240 @default.
- W2380040937 hasConcept C89423630 @default.
- W2380040937 hasConceptScore W2380040937C105702510 @default.
- W2380040937 hasConceptScore W2380040937C114851261 @default.
- W2380040937 hasConceptScore W2380040937C202751555 @default.
- W2380040937 hasConceptScore W2380040937C2777071850 @default.
- W2380040937 hasConceptScore W2380040937C2778022156 @default.
- W2380040937 hasConceptScore W2380040937C2778236110 @default.
- W2380040937 hasConceptScore W2380040937C2779548794 @default.
- W2380040937 hasConceptScore W2380040937C2780917455 @default.
- W2380040937 hasConceptScore W2380040937C55493867 @default.
- W2380040937 hasConceptScore W2380040937C86803240 @default.
- W2380040937 hasConceptScore W2380040937C89423630 @default.
- W2380040937 hasLocation W23800409371 @default.
- W2380040937 hasOpenAccess W2380040937 @default.
- W2380040937 hasPrimaryLocation W23800409371 @default.
- W2380040937 hasRelatedWork W1978517873 @default.
- W2380040937 hasRelatedWork W2042944887 @default.
- W2380040937 hasRelatedWork W2054136339 @default.
- W2380040937 hasRelatedWork W2151011245 @default.
- W2380040937 hasRelatedWork W2314314753 @default.
- W2380040937 hasRelatedWork W2362086938 @default.
- W2380040937 hasRelatedWork W2372934758 @default.
- W2380040937 hasRelatedWork W2379727119 @default.
- W2380040937 hasRelatedWork W2379886776 @default.
- W2380040937 hasRelatedWork W2382079582 @default.
- W2380040937 hasRelatedWork W2393894250 @default.
- W2380040937 hasRelatedWork W2396946501 @default.
- W2380040937 hasRelatedWork W2404824196 @default.
- W2380040937 hasRelatedWork W2409426248 @default.
- W2380040937 hasRelatedWork W2885852730 @default.
- W2380040937 hasRelatedWork W2914056265 @default.
- W2380040937 hasRelatedWork W3029880179 @default.
- W2380040937 hasRelatedWork W3032305134 @default.
- W2380040937 hasRelatedWork W3185799240 @default.
- W2380040937 hasRelatedWork W3029981579 @default.
- W2380040937 isParatext "false" @default.
- W2380040937 isRetracted "false" @default.
- W2380040937 magId "2380040937" @default.
- W2380040937 workType "article" @default.