Matches in SemOpenAlex for { <https://semopenalex.org/work/W2380053008> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2380053008 abstract "Objective To investigate the effect and related mechanism of angiotensin Ⅱ(Ang Ⅱ) inducing cell senescence in rat hippocampal neurons in primary culture.Methods Primary neonatal rat hippocampal neurons were cultured.Senescence-associated β-galactosidase(SA-β-gal) staining was used to detect cell senescence induced by Ang Ⅱ in different concentrations and at different time to determine the best inducing condition.To further explore the mechanisms,the effects of AT1 receptor blocker irbesartan and AT2 receptor blocker PD123319 on Ang Ⅱ-induced cell senescence were examined.Expressions of cell cycle-related protein P53 and P21 were detected by Western blot assay.Results Forty-eight his incubation of Ang Ⅱ(10 μmol/L) could induce cell senescence in primary rat hippocampal neurons.Irbesartan could inhibit cell senescence induced by Ang Ⅱ and reduce the expression of P53 and P21,whereas PD123319 had no effect on both of them.Conclusion Ang Ⅱ can induce cell senescence in the primary rat hippocampal neurons.The effect of Ang Ⅱ on cell senescence may be mediated by AT1 receptor and the mechanism may be related to the over-expression of protein P53 and P21." @default.
- W2380053008 created "2016-06-24" @default.
- W2380053008 creator A5063592417 @default.
- W2380053008 date "2013-01-01" @default.
- W2380053008 modified "2023-09-24" @default.
- W2380053008 title "Role of angiotensin II inducing cell senescence in rat hippocampal neurons in primary culture" @default.
- W2380053008 hasPublicationYear "2013" @default.
- W2380053008 type Work @default.
- W2380053008 sameAs 2380053008 @default.
- W2380053008 citedByCount "0" @default.
- W2380053008 crossrefType "journal-article" @default.
- W2380053008 hasAuthorship W2380053008A5063592417 @default.
- W2380053008 hasConcept C123915805 @default.
- W2380053008 hasConcept C126322002 @default.
- W2380053008 hasConcept C134018914 @default.
- W2380053008 hasConcept C148762608 @default.
- W2380053008 hasConcept C1491633281 @default.
- W2380053008 hasConcept C170493617 @default.
- W2380053008 hasConcept C185592680 @default.
- W2380053008 hasConcept C2780259554 @default.
- W2380053008 hasConcept C2908929049 @default.
- W2380053008 hasConcept C522857546 @default.
- W2380053008 hasConcept C54355233 @default.
- W2380053008 hasConcept C55493867 @default.
- W2380053008 hasConcept C71924100 @default.
- W2380053008 hasConcept C81885089 @default.
- W2380053008 hasConcept C84393581 @default.
- W2380053008 hasConcept C86803240 @default.
- W2380053008 hasConcept C95444343 @default.
- W2380053008 hasConceptScore W2380053008C123915805 @default.
- W2380053008 hasConceptScore W2380053008C126322002 @default.
- W2380053008 hasConceptScore W2380053008C134018914 @default.
- W2380053008 hasConceptScore W2380053008C148762608 @default.
- W2380053008 hasConceptScore W2380053008C1491633281 @default.
- W2380053008 hasConceptScore W2380053008C170493617 @default.
- W2380053008 hasConceptScore W2380053008C185592680 @default.
- W2380053008 hasConceptScore W2380053008C2780259554 @default.
- W2380053008 hasConceptScore W2380053008C2908929049 @default.
- W2380053008 hasConceptScore W2380053008C522857546 @default.
- W2380053008 hasConceptScore W2380053008C54355233 @default.
- W2380053008 hasConceptScore W2380053008C55493867 @default.
- W2380053008 hasConceptScore W2380053008C71924100 @default.
- W2380053008 hasConceptScore W2380053008C81885089 @default.
- W2380053008 hasConceptScore W2380053008C84393581 @default.
- W2380053008 hasConceptScore W2380053008C86803240 @default.
- W2380053008 hasConceptScore W2380053008C95444343 @default.
- W2380053008 hasLocation W23800530081 @default.
- W2380053008 hasOpenAccess W2380053008 @default.
- W2380053008 hasPrimaryLocation W23800530081 @default.
- W2380053008 hasRelatedWork W1424629852 @default.
- W2380053008 hasRelatedWork W1971729973 @default.
- W2380053008 hasRelatedWork W1974284080 @default.
- W2380053008 hasRelatedWork W1976416423 @default.
- W2380053008 hasRelatedWork W1983528779 @default.
- W2380053008 hasRelatedWork W2002501384 @default.
- W2380053008 hasRelatedWork W2008695633 @default.
- W2380053008 hasRelatedWork W2020717770 @default.
- W2380053008 hasRelatedWork W2061444919 @default.
- W2380053008 hasRelatedWork W2073604201 @default.
- W2380053008 hasRelatedWork W2100832292 @default.
- W2380053008 hasRelatedWork W2138517493 @default.
- W2380053008 hasRelatedWork W2140137540 @default.
- W2380053008 hasRelatedWork W2156460645 @default.
- W2380053008 hasRelatedWork W2412112476 @default.
- W2380053008 hasRelatedWork W2415301032 @default.
- W2380053008 hasRelatedWork W2885045451 @default.
- W2380053008 hasRelatedWork W2921298938 @default.
- W2380053008 hasRelatedWork W3115928316 @default.
- W2380053008 hasRelatedWork W3148288216 @default.
- W2380053008 isParatext "false" @default.
- W2380053008 isRetracted "false" @default.
- W2380053008 magId "2380053008" @default.
- W2380053008 workType "article" @default.