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- W2380055608 abstract "Purpose To observe the effect of aprotinin (APR) on endothelial cell(EC) activation. Methods Sixteen patients undergoing valve replacements were included in this study.Patients were randomly divided into two groups ( n=8 ):control group and APR group(APR 3×10 6(kIU).The plasma were collected from all patients before operation,CPB 30 min,30 min after declamping,post operation day 1 and 2 (POD1,POD2).Human umbilical vein endothelial cells were cultured,Cell ELISA was used to measure the expression of ICAM 1 on HUVEC,which was stimulated by plasma.Isotope label method was conducted to investigate the changes of PMN adhesion to HUVEC,which was stimulated in the plasma from 30 min after declamping. Results In the control group,the expression of ICAM 1 on HUVEC was higher than in the APR group( P 0.05).Plasma from control group increased PMN adhesion to HUVEC significantly compared with those in APR(34.2% and 58.7%,respectively, P 0.05). Conclusions Aprotinin could inhibit the activation of EC,and attenuate CPB induced inflammatory response." @default.
- W2380055608 created "2016-06-24" @default.
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- W2380055608 date "2003-01-01" @default.
- W2380055608 modified "2023-09-25" @default.
- W2380055608 title "Effect of Aprotinin on Endothelial Cell Activation in Cardiopulmonary Bypass" @default.
- W2380055608 hasPublicationYear "2003" @default.
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