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- W2380070044 abstract "Aim To investigate the influnce of simvastatin on serum LDL oxidation and platelet activation in CAD patients. Methods 38 CAD patients and 38 normal subjects were enrolled. The serum level of ox LDL、 TXB 2 and the levels of alpha granule membrane protein (GMP 140) on the surface of platelet were measured before and after the simvastatin treatment four weeks. The relationship between ox LDL、 GMP 140、 TXB 2 and HDL was analysed. Results The level of serum HDL was significantly increased in CAD patients group after simvastatin treatment four weeks. Serum ox LDL、TXB 2 and the level of GMP 140 were decreased significantly after treatment although still below the normal level.The positive correlation was found between ox LDL and GMP 140、 TXB 2. Conclusion The study confirms that simvastatin treatment may increase serum HDL and by increasing HDL, it may effectively refrain the LDL oxidation and platelet activity. It also reveals that there being a partial relation between the atherosclerotic lesions and the thrombogenicity during atherosclerotic progresion." @default.
- W2380070044 created "2016-06-24" @default.
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- W2380070044 date "1999-01-01" @default.
- W2380070044 modified "2023-09-25" @default.
- W2380070044 title "The Influnce of the Simvastatin on Serum Low Density Lipoprotein Oxidation and Platelet Activation in Coronary Artery Disease Patients" @default.
- W2380070044 hasPublicationYear "1999" @default.
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