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- W2380075151 abstract "Objective To evaluate the pathologic and biochemical changes of metachromatic leukodystrophy (MLD) in magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy ( 1 H MRS). Methods Three children were diagnosed MLD by clinical signs and decreasing arylsulfastase A in leukocyte of blood. The whole brain was scanned by using MRI, and 1 H MRS was performed in the areas of basal ganglia and white matter close to occipital angle of ventricle. Ten matched normal children were randomly choosen as controls. Results In the three cases, two were normal in the clinical and MRI examination, one was found widespread, symmetrical periventricular high signal intensity in the white matter of the cerebral hemispheres on T2WI. In the three cases, NAA/Cr were 52%-70%(areas of basal ganglia) and 46%-77%(white matter close to occipital angle of ventricle),mI/Cr were 135%-277%(basal ganglia) and 167%-303%(white matter),mI/NAA were 212%-444%(basal ganglia) and 193%-660%(white matter) as controls. Conclusion The changes of MRI and 1 H MRS in the MLD's brains can reflect the abnormal pathologic and biochemical process. Especially 1 H MRS can detect early functional changes before structural changes occur. [" @default.
- W2380075151 created "2016-06-24" @default.
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- W2380075151 date "2003-01-01" @default.
- W2380075151 modified "2023-09-25" @default.
- W2380075151 title "MRI and ~1 H -MRS Findings in Familial Metachromatic Leukodystrophy: 3 Cases Report and Review of Literatures" @default.
- W2380075151 hasPublicationYear "2003" @default.
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