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- W2380086641 abstract "To define the important role of mannose in mediating adherence of dimorphic Candida albicans to human buccal epithelial cells (BEC).Yeast forms and hyphal forms of Candida albicans were used respectively to bind with BEC in vitro. Concanavalin A(ConA), a lectin which could recognize mannose, was used to pretreat dimorphic Candida albicans, and then repeated adherence test, the adherence rates of hyphal forms with that of yeast forms was compared. Through Gas chromatographic(GC) assay of mannose in cell walls of dimorphic Candida albicans, the mannose mediated adherence of dimorphic Candida albicans to BEC was studied.The results showed that adherence rates of hyphal forms were higher than that of yeast forms. After treating the hyphal forms and yeast forms with ConA and repeating the adherence test, the adherence rates reduced remarkably. Compared with the adherence rates of ConA treated,and that without con A, the difference is remarkable. GC assay of mannose in cell walls of yeast form and hyphal forms of Candida albicans(10 6 cells) were 33±2.11μg, 151±9.96μg, respectively. It coududes that mannose in cell walls of Candida albicans is important to mediate the adherence of dimorphic Candida albicans to BEC and the content of mannose in cell walls of hyphal forms was much higher than that of yeast forms. The adherence of hyphal forms of Candida albicans to BEC was stronger than that of yeast forms." @default.
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- W2380086641 date "2004-01-01" @default.
- W2380086641 modified "2023-09-25" @default.
- W2380086641 title "The important role of mannose in mediating adherence of dimorphic Candida albicans" @default.
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