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- W2380096638 abstract "Objective To explore the effects of the Yishenhuoxue Capsule(YSHXC) on the proliferation of vascular smooth muscle cells(VSMCs) induced by HCY in rabbits.Methods VSMCs were cultured by tissue explants in vitro and proliferation was induced by HCY.Cells were divided into four groups: the control group, the HCY group,the Yishenhuoxue group and the folic acid group.The proliferation of cells,the expression of PCNA and cell cycles were determined by MTT,immunohistochemistry and flow cytometric technique.Results After being separately incubated with Yishenhuoxue and folic acid,the expression of PCNA was effectively reduced(P0.01) and that was especially in the Yishenhuoxue group(P0.05).Cell cycles were also homologically changed.Compared with the HCY group,the cell number of the Yishenhuoxue group in the G0/G1 period was increased while in the S period was decreased,which showed that the cell number in the synthesis period of DNA went down remarkably(P0.01).Conclusion Yishenhuoxue can significantly inhibit the proliferation of cells induced by HCY and bring down the level of PCNA,which may be related to a change of the cell cycle. Therefore,the Yishenhuoxue Capsule can delay the process of atheroscleorsis at an earlier period." @default.
- W2380096638 created "2016-06-24" @default.
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- W2380096638 date "2007-01-01" @default.
- W2380096638 modified "2023-09-28" @default.
- W2380096638 title "Inhibitory effect of the Yishenhuoxue Capsule on the proliferation of vascular smooth muscle cells induced by HCY in rabbits" @default.
- W2380096638 hasPublicationYear "2007" @default.
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