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- W2380097788 abstract "Objective To compare the effect of radio frequency ablation (RFA ), transcatheter artery embolization(TAE), selective portal vein embolization(SPVE) and TAE combined with SPVE in the treatment of hepatic VX 2 tumors. Methods The VX 2 hepatoma model was replicated with the method of implantation in rabbits. The animals were treated with RFA, TAE, SPVE and TAE plus SPVE. Experimental rabbits were divided into four groups: RFA, TAE, SPVE, and TAE plus SPVE. Results ① After treatment, ALT increased most significantly on the first day but decreased most slowly during 4th 7th days in TAE+SPVE group. In RFA group, however, ALT was the lowest on the first day but decreased most rapidly during 4th 7th days. It was markedly lower on the 1st, 4th and 7th days in SPVE group than that in SPVE+TAE group. ② CT scans showed cumulation of lipiodol in the foci in all the 3 vascular embolization groups in the 2nd week. Macroscopic and microscopic observations revealed the tumors became harder after embolization while biopsy demonstrated larger necrotic scope of the foci and much more hyperplastic fibrous tissue in TAE group and TAE+SPVE group than those in SPVE group. However, the necrosis in the vascular embolization groups was incomplete. ③ In the 2nd week after treatment, complete necrotic rate of the foci was significantly higher in RFA group than that in SPVE group and in TAE group. The rate of metastases in lungs was significantly lower in RFA group than that in TAE group. The survival rate was 50% in 3 months in RFA group. Animals in other 3 groups gradually died in 2 months. The average survival time was significantly longer in RFA group than that in other groups. Conclusion SPVE, TAE and SPVE combined with TAE have obvious effect on the vascular embolism of hepatic VX 2 tumor. However, the vascular embolization can not lead to complete destruction of the tumor and may bring about severer injury to the liver. Compared with the methods of vascular embolization, RFA is of better effect and less injury in the treatment of hepatoma in rabbits." @default.
- W2380097788 created "2016-06-24" @default.
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- W2380097788 date "2003-01-01" @default.
- W2380097788 modified "2023-09-25" @default.
- W2380097788 title "Hepatic VX_2 tumor in rabbits: treatment with radio frequency ablation versus vascular embolization" @default.
- W2380097788 hasPublicationYear "2003" @default.
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